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Study of the mechanism of the inhibitory effect of yeast RNA-tiloron molecular complexes on HIV-I reproductionin vitro

  • Microbiology and Immunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Time characteristics of anti-HIV activity of the yeast RNA-tiloron molecular complex are studiedin vitro and the antiviral effect is compared with the effectiveness of low temperature of incubation and the effects of azidothymidine, larifan, and poly(I)-poly(C). The effectiveness of cell protection against the cytopathogenic activity of HIV-1 and the levels of p24 antigen in culture medium and cell lysates were studied in MT-4 cells infected with HIV-I/IIIB. The molecular complex had the highest inhibitory effect at the stage of virus penetration in the cell. The probable mechanism of its anti-HIV activity is discussed.

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Authors and Affiliations

  1. Department of Interferon and Immunomodulators, Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kiev, Ukraine

    A. B. Karpov, S. V. Antonenko, E. V. Barbasheva & N. Ya. Spivak

  2. Department of General Virology, Kiev Institute of Epidemiology and Infectious Diseases, Ministry of Health of Ukraine, Ukraine

    A. B. Karpov, S. V. Antonenko, E. V. Barbasheva & N. Ya. Spivak

Authors
  1. A. B. Karpov
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  2. S. V. Antonenko
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  3. E. V. Barbasheva
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  4. N. Ya. Spivak
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 10, pp. 433–435, October, 1998

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Karpov, A.B., Antonenko, S.V., Barbasheva, E.V. et al. Study of the mechanism of the inhibitory effect of yeast RNA-tiloron molecular complexes on HIV-I reproductionin vitro . Bull Exp Biol Med 126, 1028–1030 (1998). https://doi.org/10.1007/BF02447312

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  • DOI: https://doi.org/10.1007/BF02447312

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