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New growth hormone secretagogues

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Abstract

Starting from EP 51389, a potent growth hormone secretagogue(GHS), a new series of GHS has been designed, synthesized andtested. This series was built on a gem-diamino moiety and astructure activity relationship study was performed includingN-methylation of the amide bonds. Some analogues exhibited morepowerful activity than Hexarelin, they were active peros on dog and have been selected as candidates for furtherdevelopment.

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Authors and Affiliations

  1. Laboratoire des Aminoacides, Peptides et Protéines (LAPP), UMR 5810, Université Montpellier I et II, B.P. 14491, Faculté de Pharmacie, 15 avenue Charles Flahaut, 34093, Montpellier Cédex 5, France

    V. Guerlavais, D. Boeglin, J.A. Fehrentz & J. Martinez

  2. EUROPEPTIDES, 9 avenue du Marais, 95108, Argenteuil Cedex, France

    R. Deghenghi (member of the Zentaris Group, Bt. Aristote)

  3. Dept. of Experimental, Environmental Medicine and Biotechnology, School of Medicine, University of Milano-Bicocca, via Cadore 48, 20052, Monza, (MI), Italy

    V. Locatelli

Authors
  1. V. Guerlavais
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  2. D. Boeglin
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  3. J.A. Fehrentz
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  4. R. Deghenghi
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  5. V. Locatelli
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  6. J. Martinez
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Correspondence to J.A. Fehrentz.

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Guerlavais, V., Boeglin, D., Fehrentz, J. et al. New growth hormone secretagogues. Letters in Peptide Science 8, 187–193 (2001). https://doi.org/10.1023/A:1016293500452

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  • DOI: https://doi.org/10.1023/A:1016293500452

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