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Circadian variations in the metabolic reaction of human blood lymphocytes to hormonal stimuli in health and immunodeficiency

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Circadian variations in the sensitivity of blood lymphocyte succinate dehydrogenase to thymalin and hydrocortisone are shown. The maximal sensitivity to thymalin is observed in the morning, and to hydrocortisone in the evening. The range of fluctuations in this parameter is wider in patients with immunodeficiency than in donors. Moreover, the direction of the lymphocyte metabolic reaction to the studied agents was found to be disturbed in the patients. The findings may be useful for designing chronotherapeutic schemes with the use of hormonal immunomodulating agents.

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Authors and Affiliations

  1. Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    V. A. Trufakin, A. V. Shurlygina, T. I. Dergacheva & G. I. Litvinenko

Authors
  1. V. A. Trufakin
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  2. A. V. Shurlygina
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  3. T. I. Dergacheva
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  4. G. I. Litvinenko
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No 2, pp. 181–183, February, 1995

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Trufakin, V.A., Shurlygina, A.V., Dergacheva, T.I. et al. Circadian variations in the metabolic reaction of human blood lymphocytes to hormonal stimuli in health and immunodeficiency. Bull Exp Biol Med 119, 173–175 (1995). https://doi.org/10.1007/BF02445870

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  • DOI: https://doi.org/10.1007/BF02445870

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