Abstract
The effects of amiridine and of the comparable drugs tacrine and piracetam on synaptosomes and membranes of sarcoplasmic reticulum were studied by electron paramagnetic resonance; in addition, the effects of these drugs on the activity of Ca2+, Mg2+-dependent ATPase regulating calcium transport in neurons were investigated. In concentrations of 10−7 to 10−5 M the drugs did not affect the structure of synaptosomal membranes of rat brain. Amiridine and tacrine in a concentration of 0.1 mM reduced the rate of calcium ion transport across the sarcoplasmic reticulum membrane by inhibiting the function of Ca2+, Mg2+-dependent ATPase and induced marked changes of the structural rigidity of the protein part of the membrane.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N№ 11, pp. 503–505, November, 1995
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Burov, Y.V., Tat'yanenko, L.V., Kharakhonycheva, N.V. et al. Comparative study of the effect of amiridine on biological membranes. Bull Exp Biol Med 120, 1125–1127 (1995). https://doi.org/10.1007/BF02445482
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DOI: https://doi.org/10.1007/BF02445482