Abstract
Glycyrram is a plant preparation containing 2d-glucuronic acid residues, a component of extracellular matrix of the bone marrow. Glycyrram is shown to stimulate restoration of granulomonocyto- and erythropoiesis under conditions of cytostatic myelosuppression induced by 5-fluorouracil or cyclophosphamide. The preparation elevates the contents of both morphologically discernible elements and committed precursors. Myelotropic effect of glycyrram is not related to its direct action on hemopoietic cells but depends on stimulation of hemopoietic microenvironment.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 5, pp. 555–559, May, 1997
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Zhdanov, V.V., Lyubavina, P.A., Kirienkova, E.V. et al. Mechanisms of hemostimulating effect of glycyrram. Bull Exp Biol Med 123, 483–487 (1997). https://doi.org/10.1007/BF02445326
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DOI: https://doi.org/10.1007/BF02445326