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Different antiarrhythmic effects of dalargin and β-endorphin in severe myocardial ischemia during stimulation of the sensorimotor cortex

  • General Pathology and Pathological Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effects of the opiate receptor agonists dalargin and β-endorphin on the occurrence of idioventricular arrhythmias, including ventricular tachycardia and fibrillation, are studied in acute experiments on Nembutal-anesthetized cats. Dalargin administered in the dose crossing the blood-brain barrier produces a pronounced antiarrhythmic effect, while β-endorphin is effective only against ventricular fibrillation.

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References

  1. L. A. Alekminskaya, Yu. B. Lishmanov, V. D. Slepushkin, and M. I. Titov,Byull. Eksp. Biol. Med.,99, No. 5, 535–537 (1985).

    Article  CAS  Google Scholar 

  2. I. O. Ivannikov,Ter. Arkh.,64, No. 12, 8–10 (1992).

    Google Scholar 

  3. G. I. Kositskii, S. D. Mikhailova, S. L. Gorozhanin,et al., Vestn. Akad. Med. Nauk SSSR, No. 12, 67–69 (1985).

    PubMed  Google Scholar 

  4. G. I. Kositskii, S. D. Mikhailova, S. L. Gorozhanin,et al., Kardiologiya, No. 5, 89–91 (1987).

    Google Scholar 

  5. G. I. Kositskii, S. D. Mikhailova, S. V. Putygin,et al., Pat. Fiziol., No. 6, 31–35 (1980).

    Google Scholar 

  6. Yu. B. Lishmanov, L. N. Maslov, and D. S. Ugdyzhekova,Eksp. Klin. Farmakol., No. 4, 26–28 (1995).

    Google Scholar 

  7. F. Z. Meerson,Pathogenesis and Prevention of Stress-Induced Ischemic Damage to the Heart [in Russian], Moscow (1984).

  8. F. Z. Meerson, A. D. Dmitriev, and V. I. Zayats,Kardiologiya, No. 9, 81–88 (1984).

    Google Scholar 

  9. V. D. Slepushkin, G. K. Zoloev, and V. A. Vinogradov,Neuropeptides: Their Role in Physiology and Pathology [in Russian], Tomsk (1988).

  10. K. N. Yarygin, in:Oligopeptides as Regulators of the Organism's Functions [in Russian], Moscow (1987), pp. 24–30.

  11. V. V. Yasnetsov, V. A. Pravdivtsev, and V. G. Motin,Byull. Eksp. Biol. Med.,98, No. 12, 687–690 (1984).

    CAS  Google Scholar 

  12. R. A. Houghten, R. W. Swann, and C. H. Li,Proc. Natl. Acad. Sci. USA,77, 4588–4591 (1980).

    Article  PubMed  CAS  Google Scholar 

  13. B. Lown, R. L. Verrier, and S. H. Rabinovitz,Am. J. Cardiol.,39, 890–902 (1977).

    Article  PubMed  CAS  Google Scholar 

  14. C. Van Loon, N. Appel, and H. Doris,Endocrinology,109, 46–53 (1981).

    Article  PubMed  Google Scholar 

  15. M. Wuster, R. Schulz, and A. Herz,Neurosci. Lett.,5, 193–198 (1978).

    Google Scholar 

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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 7, pp. 28–31, July, 1997

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Mikhailova, S.D., Storozhakov, G.I., Kudinova, A.V. et al. Different antiarrhythmic effects of dalargin and β-endorphin in severe myocardial ischemia during stimulation of the sensorimotor cortex. Bull Exp Biol Med 124, 645–647 (1997). https://doi.org/10.1007/BF02445050

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  • DOI: https://doi.org/10.1007/BF02445050

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