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Antithrombogenic effect of urokinase bound to collagen substrate with bifunctional antibodies

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In vitro experiments simulating collagen-induced thrombogenesis in arteries damaged during angioplasty demonstrate a marked inhibitory effect of surface-bound urokinase. In contrast to free urokinase, bound enzyme is more effective in preventing platelet aggregation on the collagen surface.

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Authors and Affiliations

  1. Group of Engineering Immunology, Cardiological Research Center, Russian Academy of Medical Sciences, Moscow

    I. P. Stepanova, M. V. Tsybul'skaya & S. P. Domogatskii

Authors
  1. I. P. Stepanova
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  2. M. V. Tsybul'skaya
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  3. S. P. Domogatskii
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, No 5, pp. 504–507, May, 1994

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Stepanova, I.P., Tsybul'skaya, M.V. & Domogatskii, S.P. Antithrombogenic effect of urokinase bound to collagen substrate with bifunctional antibodies. Bull Exp Biol Med 117, 502–505 (1994). https://doi.org/10.1007/BF02444301

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  • DOI: https://doi.org/10.1007/BF02444301

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