Summary
In 31 epileptics, most of whom had been on anticonvulsive drugs for decades, the amount of osteoid—active and inactive—and the osteoclast activity were measured in iliac crest biopsies and compared with the same variables from a control group. Although falling within normal limits, the amount of osteoid, in particular the inactive osteoid, was significantly increased in the epileptics. The osteoclast activity was also significantly increased in the epileptics.
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Kruse, R: Osteopathien bei antiepileptischer Langzeittherapie, Monatsschr. Kinderheilkd.116:378–380, 1968
Richens, A., Rowe, D.J.D.: Disturbance of calcium metabolism by anticonvulsant drugs, Br. Med. J.4:73–76, 1970
Hunter, J., Maxwell, J.D., Stewart, D.A., Parsons, B., Williams, R.: Altered calcium metabolism in epileptic children on anticonvulsants, Br. Med. J.4:202–204, 1971
Christiansen, C., Rödbro, P., Lund, M.: Incidence of anticonvulsant osteomalacia and effect of vitamin D: controlled therapeutic trial, Br. Med. J.4:695–701, 1973
Sotaniemi, E.A., Hakkarainen, H.K., Puranen, J.K., Lahti, R.O.: Radiologic bone changes and hypocalcemia with anticonvulsant therapy in epilepsy, Ann. Intern. Med.77:389–394, 1972
Hahn, T.J., Hendin, B.A., Scharp, C.R., Boisseau, V.C., Haddad, J.G.: Serum 25-hydroxycalciferol levels and bone mass in children on chronic anticonvulsant therapy, N. Engl. J. Med.292:550–554, 1975
Dent, C.E., Richens, A., Rowe, D.J.F., Stamp, T.C.B.: Osteomalacia with long-term anticonvulsant therapy in epilepsy, Br. Med. J.4:69–72, 1970
Mosekilde, L., Melsen, F.: Anticonvulsant osteomalacia determined by quantitative analysis of bone changes, Acta Med. Scand.199:349–355, 1976
Lidgren, L., Wallöe, A.: Incidence of fractures in epileptics, Acta Orthop. Scand.48:356–361, 1977
Dymling, J.F., Lidgren, L., Wallöe, A: Biochemical variables related to calcium metabolism in epileptics, Acta Med. Scand. (in press)
Burkhardt, R.: Technische Verbesserungen und Anwendungsbereich der Histo-Biopsie von Knochenmark und Knochen, Klin. Wochenschr.44:326, 1966
Goldner, J.: A modification of the Masson trichrome technique for routine laboratory purposes, Am. J. Pathol.14:237–243, 1938
Merz, W.A., Schenk, R.K.: Quantitative structural analysis of human cancellous bone, Acta Anat. (Basel)75:54–66, 1970
Johnell, O., Wiklund, P.E., Hulth, A.: Osteoclast counting in crista biopsies, Acta Orthop. Scand.48:566–571, 1977
Aaron, J.E.: In B.E.C. Nordin (ed.): Calcium, Phosphate and Magnesium Metabolism, p. 349. Churchill Livingstone, Edinburgh, 1976
Schenk, R.K., Merz, W.A., Müller, J.: A quantitative histological study on bone resorption in human cancellous bone, Acta Anat. (Basel)74:44–53, 1969
Jowsey, J., Kelly, P.J., Riggs, B.L., Bianco, A.J., Scholz, D.A., Gershon-Cohen, J.: Quantitative microradiographic studies of normal and osteoporotic bone, J. Bone Joint Surg.47A:785–806, 1965
Bordier, P., Ryckwaert, A., Marie, P., Miravet, L., Norman, A., Rasmussen, H.: Vitamin D metabolites and mineralisation in man. In A.W. Norman, K. Schaefer, J.W. Coburn, H.F. DeLuca, D. Fraser, H.G. Grigoleit, D. von Herrath, (eds.): Vitamin D. Biochemical, Chemical and Clinical Aspects Related to Calcium Metabolism, pp. 897–911. de Gruyter, Berlin-New York, 1977
Rödbro, P., Christiansen, C., Lund, M.: Development of anticonvulsant osteomalacia in epileptic patients on phenytoin treatment, Acta Neurol. Scand.50:527–532, 1974
Nilsson, B.E., Westlin, N.E.: Bone mineral content and fragility fractures, Clin. Orthop.125:196–199, 1977
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Johnell, O., Nilsson, B.E., Wallöe, A. et al. Bone morphology in epileptics. Calcif Tissue Int 28, 93–97 (1979). https://doi.org/10.1007/BF02441225
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DOI: https://doi.org/10.1007/BF02441225