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Structural and metabolic status and functional peculiarities of erythrocytes in children with insulin-dependent diabetes mellitus

  • Experimental Methods for Clinical Practice
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Development of insulin-dependent diabetes mellitus in children is accompanied by essential disturbances in the peripheral subdivision of the erythron system, manifested in enhanced cell polymorphism, imbalance in the composition of membrane phospholipids and their increased microviscosity, reduced lipoprotein concentration, and enhanced reversible aggregation. These disturbances are most pronounced during metabolic decompensation accompanied by ketoacidosis, which agrees with the hypothesis on their role in the development of vascular complications.

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Authors and Affiliations

  1. Siberian State Medical University, Tomsk

    V. V. Novitskii, M. V. Kolosova, E. B. Kravets, E. A. Stepovaya, G. P. Filippov, Ya. A. Dorovskikh, E. P. Tarkhova & Ya. V. Bulavina

  2. Institute of Pharmacology, Tomsk

    V. V. Novitskii, M. V. Kolosova, E. B. Kravets, E. A. Stepovaya, G. P. Filippov, Ya. A. Dorovskikh, E. P. Tarkhova & Ya. V. Bulavina

  3. Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk

    V. V. Novitskii, M. V. Kolosova, E. B. Kravets, E. A. Stepovaya, G. P. Filippov, Ya. A. Dorovskikh, E. P. Tarkhova & Ya. V. Bulavina

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  1. V. V. Novitskii
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  2. M. V. Kolosova
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  3. E. B. Kravets
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  4. E. A. Stepovaya
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  5. G. P. Filippov
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  6. Ya. A. Dorovskikh
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  7. E. P. Tarkhova
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  8. Ya. V. Bulavina
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Novitskii, V.V., Kolosova, M.V., Kravets, E.B. et al. Structural and metabolic status and functional peculiarities of erythrocytes in children with insulin-dependent diabetes mellitus. Bull Exp Biol Med 128, 959–962 (1999). https://doi.org/10.1007/BF02438097

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  • DOI: https://doi.org/10.1007/BF02438097

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