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Biological activity and pharmacological properties of anticoagulant complex (Hirudin, plasma kallikrein inhibitor, prostaglandin) fromHirudo Medicinalis

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Antiprocoagulant complex isolated from lyophilized medicinal leeches exerted pronounced antithrombotic, thrombolytic, and hypotensive effects in experimental animals after intravenous injection and showed antithrombotic activity after oral administration in combination with hirudone, the source of hyaluronidase and inhibitors of digestive proteolytic enzymes. The antiprocoagulant complex can be used as a specific medicinal preparation.

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References

  1. I. P. Baskova and G. I. Nikonov,Dokl. Akad. Nauk SSSR,292, 1492–1493 (1987).

    PubMed  CAS  Google Scholar 

  2. G. I. Nikonov,Medicinal Leech. Yesterday, Today, Tomorrow [in Russian], Moscow (1992).

  3. E. A. Titova and G. I. Nikonov,Progress in Hirudology and Hirudotherapy [in Russian], Ed. A. I. Krashenyuk, S. Petersburg (1994).

  4. I. P. Baskova and G. I. Nikonov,Blood Coagul. Fibrinolysis,2, 167–172 (1991).

    PubMed  CAS  Google Scholar 

  5. I. P. Baskova, S. Khalil, and G. I. Nikonov,Biochem. Res. Commun.,103, 552–558 (1991).

    Google Scholar 

  6. F. Herman, P. Hadhazy, and K. Magyar,Thromb. Haemost.,58, 179 (1987).

    Google Scholar 

  7. O. H. Lowry, N. Y. Rosenlough, and A. L. Farr,J. Biol. Chem.,193, 266–273 (1951).

    Google Scholar 

  8. F. Markwardt,Prothrombin and Related Coagulation Factors, Leiden (1989), pp. 116–131.

  9. J. Misial, M. Wilozinska, and K. Sladek,Prostaglandins,31, 61–71 (1986).

    Article  Google Scholar 

  10. R. T. Sawyer,Leech Biology and Behavior, vol. 1. Oxford (1986).

  11. L. Swendsen, R. Blomback, and M. Blomback,Thromb. Res.,1, 267–278 (1972).

    Article  Google Scholar 

  12. K. Weber and M. Osborne,J. Biol. Chem.,244, 4406–4412 (1969).

    PubMed  CAS  Google Scholar 

  13. S. Wessler, L. Reiner, and D. C. Freiman.,Circulation,120, 864–867 (1959).

    Google Scholar 

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Authors and Affiliations

  1. BIOKON, Medical Research-and-Production Company, Moscow Region

    G. I. Nikonov, E. A. Titova & K. G. Seleznev

  2. ROSFARMATSIYA Joint-Stock Company, Moscow Region

    G. I. Nikonov, E. A. Titova & K. G. Seleznev

Authors
  1. G. I. Nikonov
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  2. E. A. Titova
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  3. K. G. Seleznev
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 12, pp. 673–676, December, 1999

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Nikonov, G.I., Titova, E.A. & Seleznev, K.G. Biological activity and pharmacological properties of anticoagulant complex (Hirudin, plasma kallikrein inhibitor, prostaglandin) fromHirudo Medicinalis . Bull Exp Biol Med 128, 1244–1247 (1999). https://doi.org/10.1007/BF02434830

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  • DOI: https://doi.org/10.1007/BF02434830

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