Abstract
Sixteen month old C57BL/6J male mice were fed either a nutritionally adequate diet or this diet diluted with either 33% or 50% cellulose. The life span of the animals fed the latter two diets was longer than that of the controls, but only statistically significant in the animals fed the diet diluted with 50% cellulose. The rates of cellular protein synthesis were estimated in liver by determining: 1) the half lives of proteins by the rate of disappearance of radioactivity following the intraperitoneal injection of C14 labeled sodium bicarbonate, and 2) the cellular protein levels estimated by the concentration of proteins and DNA of the tissue. The rates of disappearance of radioactivity from the liver proteins of mice were not statistically significantly affected by these dietary regimens. However, there was a 27% decrease in the cellular protein synthesis of liver in the animals fed the diets containing cellulose.
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Kokkonen, G.C., Barrows, C.H. The effect of dietary cellulose on life span and biochemical variables of male mice. AGE 11, 7–9 (1988). https://doi.org/10.1007/BF02431758
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DOI: https://doi.org/10.1007/BF02431758