Abstract
From December 1982 to June 1985, we diagnosed LAV/HTLV-III infection in 16 children of African origin living in Belgium or referred to one of the hospitals participating in this study. Diagnosis was proven in seven of them by isolation of virus of the LAV/HTLV-III group. In the nine others, LAV/HTLV-III infection was highly probable because of the presence of antibodies against the virus (seven subjects) or clinical and immunological evidence of immune deficiency associated with a parental history of LAV/HTLV-III infection (two subjects). Five of these children had a severe illness starting in the first months of life (range 20 days-4 months) and died within 4 months (range 19 days-10 months). Eight children presented later in life (mean age 35 months, range 2–66 months) with a milder and more chronic disease characterized by the presence of generalized lymphadenopathy (6/8), hepatomegaly (5/8), splenomegaly (5/8), interstitial pulmonary infiltration (4/8), parotid swelling (3/8), CSF lymphocytosis (3/5), diarrhoea without pathogen isolated (1/8) and fever (1/8).
At least one of the parents of each child was of African origin. At the time of birth of their child two mothers and one father had an AIDS-related complex. After a mean period of 34 months (range 3–87 months) five fathers and six mothers had a symptomatic LAV/HTLV-III infection (AIDS or AIDS-related complex).
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Abbreviations
- AIDS:
-
acquired immune deficiency syndrome
- ARC:
-
AIDS-related complex
- HTLV-III:
-
human T-cell lymphotrophic virus III
- LAV:
-
lymphadenopathy-associated virus
- CMV:
-
cytomegalovirus
- PCP:
-
pneumocystic carinii pneumonia
- CDC:
-
center for disease control, Atlanta, USA
References
Abrams DI, Lewis BJ, Beckstead JH, Casavaux CA, Drew WL (1984) Persistent diffuse lymphadenopathy in homosexual men: endpoint or prodrome. Ann Intern Med 100:801–807
Barré-Sinoussi F, Chermann JC, Rey F, Nugeyre M, Chamaret S, Gruest J, Dauguet C, Axler-Blein C, Vézinet-Brun F, Rouzioux C, Rozenbaum W, Montagnier L (1983) Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 220:868–871
Cooper DA, Gold J, McLean P, Donovan B, Finlayson R, Barnes TG, Michelmore HM, Brooke P, Penny R (1985) Acute retrovirus infection. Definition of a clinical illness associated with seroconversion. Lancet 1:537–540
Current Trends (1985) Revision of the Case Definition of Acquired Immunodeficiency Syndrome for National Reporting — United States. Morbid Mortal Weekly Rep 34:373–375
Epstein LG, Sharer LR, Joshi VV, Fojas MM, Koenigsberger MR, Oleske JM (1985) Progressive encephalopathy in children with Acquired immune deficiency syndrome. Ann Neurol 17: 488–496
Gallo RC, Sarin P, Gelman E, Robert-Guroff M, Richardson E, Kolyanaraman VS, Mann Dean, Sidhn GD, Stahl RE, Zolla-Pazner S, Leibovitch J, Popovic M (1983) Isolation of a human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS). Science 220:865–868
Jonckheer T, Dab I, Van de Perre P, Lepage P, Desnoy J, Taelman H (1985) Cluster of LAV/HTLV-III infection in an African family. Lancet I:400–401
Kuman ML, Nankervis GA, Cooper A, Gold A (1984) Postnatally acquired cytomegalovirus infections in infants of CMV-excreting mothers. J Pediatr 104:669–673
Laurence J, Brun-Vézinet F, Schutzer SE, Rouzioux C, Klatzmann D, Barré-Sinoussi F, Chermann JC, Montagnier L (1984) Lymphadenopathy-associated viral antibody in AIDS. Immune correlations and definition of a carrier state. N Engl J Med 311:1269–1273
Mascart-Lemone F, Delespesse G, Servais G, Kunstler M (1982) Characterization of immunoregulatory T-lymphocytes during aging by monoclonal antibodies. Clin Exp Immunol 48:148–154
Memoranda (1984) Acquired immunodeficiency syndrome — and assessment of the present situation in the world: memorandum from a WHO Meeting. Bull WHO 62:419–432
Oleske J, Minnefor A, Cooper R, Thomas K, dela Cruz A, Ahdieh H, Guessero J, Joshi VV, Desposito F (1983) Immune deficiency syndrome in children. JAMA 249:2345–2349
Piot P, Taclman H, Minlangu KB, Mbendi N, Ndangi K, Kalambayi K, Bridts C, Quinn TC, Feinsod FM, Wobin O, Mazelo P, Stevens W, Mitchell S, McCormick JB (1984) Acquired immunodeficiency syndrome in a heterosexual population in Zaire. Lancet 1984:II:65–69
Rogers M (1985) AIDS in children: a review of the clinical, epidemiologic and public health aspects. Ped Inf Dis 4:230–236
Rubinstein A, Sicklick N, Gupta, Bernstein L, Klein N, Rubinstein E, Spigland I, Fruchter L, Litman N, Lee H, Hollander M. (1983) Acquired immunodeficiency with reversed T4/T8 ratios in infants born to promiscuous and drug addicted methers. JAMA 249:2350–2356
Sarngadharan MG, Popovic M, Bruch L, Scupback J, Gallo RC (1984) Antibodies reactive with Human T-lymphotropic retrovirus (HTLV III) in the serum of patients with AIDS. Science 224:506–508
Scott GB, Buck B, Leterman JG, Bloom FL, Parks WP (1984) Acquired immunodeficiency syndrome in infants. N Engl J Med 310:76–81
Shannon K, Ammann A (1985) Acquired immune deficiency syndrome in childhood. J Pediatr 106:332–342
Show GM, Harper ME, Epstein LG, Gajdusck DC, Price RW, Navia BA, Petito CK, O'Hara CJ Groopman JE, Cho ES, Oleske JM, Wong-Staal F, Gallo RC (1985) HTLV III in brains of children and adults with AIDS encephalopathy. Science 227:177–181
Thiry L, Sprecher-Goldberger S, Jacquemein P, Cogniaux J, Burny A, Bruck C, Portetelle D, Can, S, Clumeck N (1985) Bovine leukemia virus related antigens in lymphocyte cultures infected with acquired immunodeficiency syndrome viruses. Science 227:1482–1484
Thiry L, Sprecher-Goldberger S, Jonckheer T, Levy J, Van de Perre P, Henrivaux P, Cogniaux J, Clumeck N (1985) Repeated isolations of LAV/HTLV-III from cell-free breast milk samples of three healthy virus carrier mothers. Lancet I:891–892
Update (1981) Pneumocystis pneumonia. Los Angeles. Morbid Mortal. Weekly Rep 1981;30:250–252
Update (1985) Acquired Immunodeficiency Syndrome — United States. Morbid Mortal Weekly Rep 34:245–248
Van de Perre P, Lepage P, Kestelijn P, Hekker AC, Rouvroy D, Bogaerts J, Kayihigi J, Butzler JP, Clumeck N (1984) Acquired immunodeficiency syndrome in Rwanda. Lancet II:62–65
Wilson GS, Desmond MM, Verniand W (1973) Early development of infants of heroin-adicted mothers. Am J Dis Child 126: 457–462
Ziegler J, Johnson R, Cooper D, Gold J (1965) Postnatal transmission of AIDS-associated retrovirus from mother to infant. Lancet I:896–897
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Jonckheer, T., Levy, J., Van de Perre, P. et al. LAV/HTLV-III infection in children of African origin: Experience in Belgium. Eur J Pediatr 145, 511–516 (1986). https://doi.org/10.1007/BF02429054
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DOI: https://doi.org/10.1007/BF02429054