Abstract
Therapeutic irradiation is commonly used in the treatment of malignant brain tumors and has the potential to cause severe injury to normal tissues adjacent to a lesion. Computed tomography (CT) can be used not only to visualize tissue damage but to monitor the development of a lesion using advanced quantitative CT techniques. We have used a postprocessing dual energy CT method to quantify changes in tissue composition following large single doses of X-rays to the normal canine brain. The results suggest that these techniques will provide more information about the character of a lesion than is obtainable from conventional imaging procedures.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Alvarez, R.E. and A. Macovski. Energy-selective reconstructions in x-ray computerized tomography.Phys. Med. Biol. 21:733–744, 1976.
Brooks, R. A quantitative theory of the Hounsfield unit and its application to dual energy scanning.J. Comput. Assist. Tomogr. 1:487–493, 1977.
Caveness, W.F. Pathology of radiation damage to the normal brain of the monkey.Natl. Cancer Inst. Monogr. 46:57–76, 1977.
Di Chiro, G., R.A. Brooks, R.M. Kessler, G.S. Jonston, A.E. Jones, J.R. Herdt, and W.T. Sheridan. Tissue signatures with dual energy computed tomographyRadiology 13:521–523, 1979.
Fike, J.R. and C.E. Cann. Radiation effects in the canine brain quantified by CT.J. Comput. Assist. Tomogr. 7:565–566, 1983.
Fike, J.R. and C.E. Cann. Contrast medium accumulation and washout in canine brain tumors and irradiated normal brain: ACT study of kinetics.Radiology 151:115–120, 1984.
Fike, J.R., C.E. Cann, and W.H. Berninger. Quantitative evaluation of the canine brain using computed tomography.J. Comput. Assist. Tomogr. 6:325–333, 1982.
Fike, J.R., C.E. Cann, R.L. Davis, and T.L. Phillips. Radiation effects in the canine brain evaluated by quantitative computed tomography.Radiology 144:603–608, 1982.
Marshall, W.H., W. Easter, and L.M. Zatz. Analysis of the dense lesion by computed tomography with dual kVp scans.Radiology 124:87–89, 1977.
Martins, A.N., J.S. Johnston, I.M. Henry, T.I. Stoffel, and G. Di Chiro. Delayed radiation necrosis of the brain.J. Neurosurg. 47:336–345, 1977.
Mikhael, M.A., Radiation necrosis of the brain: Correlation between computed tomography pathology and dose distribution.J. Comput. Assist. Tomogr. 2:71–80, 1978.
Phelps, M.E., E.J. Hoffman, and M.M. Ter-Pogossian. Altenuation coefficients of various body tissues, fluids, and lesions at photon energies of 18 to 136 keV.Radiology 117:573–583, 1975.
Ritchings, R.T. and B.R. Pullan. A technique for simultaneous dual energy scanning.J. Comput. Assist. Tomogr. 3:842–846, 1979.
Rutherford, R.A., B.R. Pullan and I. Isherwood. Measurement of effective atomic number and electron density using an EMI scanner.Neuroradiology 11:15–21, 1976.
Sheline, G.E. Radiation therapy of brain tumors,Cancer 39:873–881, 1977.
Sheline, G.E., W.W. Wara, and V. Smith. Therapeutic irradiation and brain injury.Int. J. Radiat. Oncol. Biol. Phys. 6:1214–1228, 1980.
Zatz, L.M. The effect of the kVP level on EMI values.Radiology 119:683–688, 1976.
Zook, B.C., E.W. Bradley, G.W. Cassarett, and C.C. Rogers. Pathologic findings in canine brain irradiated with fractionated fast neutrons or photons.Radiat. Res. 89:562–578, 1980.
Author information
Authors and Affiliations
Additional information
Supported in part by PHS grant California 30445 from the National Cancer Institute (JRF) and by NIH Center Grant 13525 (JRF) and by the Radiology Research and Education Foundation.
Rights and permissions
About this article
Cite this article
Russell, L.B., Fike, J.R., Cann, C.E. et al. Dual energy CT scanning for analysis of brain damage due to X-irradiation. Ann Biomed Eng 12, 15–28 (1984). https://doi.org/10.1007/BF02410288
Issue Date:
DOI: https://doi.org/10.1007/BF02410288