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The treatement of cerebral oligodendrogliomas with particular reference to features indicating malignancy: Report of seventy-seven cases

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Abstract

Oligodendrogliomas are relatively rate tumors that arise from the oligodendrocyte or its precursors. The role of postoperative radiotherapy (RT) in these tumors still remains unclear. Data concerning a study on 77 histologically verified cases of oligodendrogliomas of the brain among a total number of 1884 cases of an intracranial glioma treated at the Hacettepe Medical Centre between 1964 and 1991 were reviewed and analyzed (6.5%). One patient died in the early postoperative period and 8 patients in pediatric age group with an aggressive from of the tumor died within 6 months of treatment. The results suggest that oligodendrogliomas which arise in childhood primarily in the intraventricular region should be considered potentially more malignant than other lesions of this type. Because of this, we believe that postoperative radiotherapy is necessary to prevent the recurrences.

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References

  1. Atasoy MA, R Pütün, E Tel: Oligodendrogliomlarda postoperatif yaşam süresi (5 olgu nedeni ile). Anadolu Tip Dergisi 10 (1988) 255–260

    Google Scholar 

  2. Barnard RD: The development of manlignancy in oligodendrogliomas. J Pathol Bacteriol 96 (1968) 113–123

    Article  CAS  PubMed  Google Scholar 

  3. Bucy PC: “It might help, it can do no harm”. Surg Neurol 5 (1976) 214 (editorial)

    Google Scholar 

  4. Cairncross JG, DR Macdonald: Successful chemotherapy for recurrent malignant oligodendroglioma. Ann Neurol 23 (1988) 460–464

    Article  Google Scholar 

  5. Cairncross JG, DR Macdonald: Chemotherapy for oligodendroglioma: progress report. Arch Neurol 48 (1991) 226–227

    Google Scholar 

  6. Cairncross JG, DR Macdonald, DA Ramsay: Aggressive oligodendroglioma: a chemosensitive tumor. Neurosurgery 31 (1992) 78–82

    CAS  PubMed  Google Scholar 

  7. Canbaz B, Z Akar, M Hanci, C Kuday, E Sayin, E Özyurt, S Akçura, H Ak, G Özçinar: 34 opere oligodendroglioma olgusunun deĝerlendirilmesi. Nörol Bil D 8 (1991) 20–23

    Google Scholar 

  8. Chin HW, JJ Hazel, TH Kim, JH Webster: Oligodendrogliomas: I. A clinical study of cerebral oligodendrogliomas. Cancer 45 (1980) 1465–1466

    Google Scholar 

  9. Cobb CA, JR Youmans: Glial and neuronal tumors of the brain. InYoumans JR (ed): Neurological Surgery. WB Saunders. Philadelphia 1982

    Google Scholar 

  10. Deda H, HZ Gökalp, E Arasil, N Yüceer: Primer lateral ventrikül oligodendrogliomlari. Türk Nöroşirürji Dergisi 4 (1994) 22–25

    Google Scholar 

  11. Dohrmann GJ, JR Farwell, JT Flannery: Oligodendrogliomas in children. Surg. Neurol 10 (1978) 21–25

    CAS  PubMed  Google Scholar 

  12. Glass J, FH Hochber, ML Gruber, DN Louis, D Smith, B Ratiner: The treatment of oligodendrogliomas and mixed oligodendroglioma-astrocytoma with PCV chemotherapy. J Neurosurg 76 (1992) 741–745

    CAS  PubMed  Google Scholar 

  13. Heiskanen O: Intracranial tumors of children. Childs Brain 3 (1977) 69–78

    CAS  PubMed  Google Scholar 

  14. Hirsch JF, CS Rose, AP Kahn, A Pfister, EH Hirsch: Benign astrocytic and oligodendrocytic tumors of the cerebral hemispheres in children. J Neurosurg 70 (1989) 568–572

    CAS  PubMed  Google Scholar 

  15. Kaplan EL, P Meier: Nonparametric estimation from incomplete observations. J Am Stat Assoc 35 (1958) 457–481

    Google Scholar 

  16. Kramer S: The hazards of therapeutic irradiation of the central nervous system. Clin Neurosurg 15 (1968) 301–318

    CAS  PubMed  Google Scholar 

  17. Kros JM, D Troost, CJ van Eden, JM van der Werf, HBM Uylings: Oligodendroglioma: a comparison of two grading systems. Cancer 61 (1988) 2251–2259

    CAS  PubMed  Google Scholar 

  18. Leibel SA, GE Sheline: Radiation therapy for neoplasms of the brain. J Neurosurg 66 (1987) 1–22

    CAS  PubMed  Google Scholar 

  19. Macdonald DR, RA O'Brien, JJ Gilbert, JG Cairncross: Metastatic anaplastic oligodendroglioma. Neurology 39 (1989) 1593–1596

    CAS  PubMed  Google Scholar 

  20. Mork SJ, KF Lindegaard, TB Halvorsen, EH Lehmann, T Solgaard, R Hatlevoli, S Harvel, J Ganz: Oligodendroglioma: incidence and biological behaviour in a defined population. J Neurosurg 63 (1985) 881–889

    CAS  PubMed  Google Scholar 

  21. Müller W, D Afra, R Schröder: Supratentorial recurrences of gliomas: morphological study in relation to time intervals with oligodendrogliomas. Acta Neurochir (Wien) 39 (1977) 15–25

    Article  Google Scholar 

  22. Önol B: Nöroektodermal orijinli primer beyin tümörlerinin pato-morfolojisi. Hacettepe Tip/Cerrahi Bülteni 4 (1971) 87–113

    Google Scholar 

  23. Packer RJ, LN Sutton, LB Roke, RA Zimmerman, P Littman, DA Bruce, L Schut: Oligodendroglioma of the posterior fossa in childhood. Cancer 56 (1985) 195–199

    CAS  PubMed  Google Scholar 

  24. Reedy DP, JW Bay, JF Hahn: Role of radiation therapy in the treatment of cerebral oligodendroglioma: an analysis of 57 cases and a literature review. Neurosurgery 13 (1983) 499–503

    CAS  PubMed  Google Scholar 

  25. Shenkin HA: The effect of roentgen-ray therapy on oligodendrogliomas of the brain. J Neurosurg 22 (1965) 57–59

    CAS  PubMed  Google Scholar 

  26. Sheline GE, EB Boldrey, P Karlsberg, TL Phillips: Therapeutic considerations in tumors affecting the central nervous system: oligodendroglioma. Radiology 82 (1964) 84–89

    CAS  PubMed  Google Scholar 

  27. Smith MT, CL Ludwig, AD Godfrey, VW Armbuztmacher: Grading of oligodendrogliomas. Cancer 52 (1983) 2107–2114

    CAS  PubMed  Google Scholar 

  28. Tekkök IH, G Ayberk, S Saĝlam, B Önol: Primary intraventricular oligodendroglioma. Neurochirurgia 35 (1992) 63–66

    PubMed  Google Scholar 

  29. Walker MD, E JR Alexander, WE Hunt, CS Maccarty, MS Mahaley, JJR Mealey, HA Norrell, G Owens, J Ranshoff, CB Wilson, EA Gehan, TA Strike: Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial. J Neurosurπg 49 (1978) 333–343

    CAS  Google Scholar 

  30. Walker MD, SB Green, DP Byar, EJR Alexander, U Batzdorf, WH Brooks, WE Hunt, CS Maccarty, MS Mahaley, JJR Mealey, G Ovens, J Ranshoff, JT Robertson, WR Shapiro, KR Smith, CB Wilson, TA Strike: Randomized comparisons of radiotherapy and nitrosureas for the treatment of malignant glioma after surgery. N Engl J Med 303 (1980) 1323–1329

    CAS  PubMed  Google Scholar 

  31. Weir B, AR Elvidge: Oligodendrogliomas: an analysis of 63 cases. J Neuosurg 29 (1968) 500–505

    Google Scholar 

  32. Wilkinson I, JR Anderson, AE Holmes: Oligodendroglioma: an analysis of 42 cases. J Neurol Neurosurg Psychiatry 50 (1987) 304–312

    CAS  PubMed  Google Scholar 

  33. Zülch KJ: Histological typing of tumours of the central nervous system. International histological classification of tumours. No. 21. WHO. Geneve 1979

    Google Scholar 

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Authors and Affiliations

  1. Department of Neurosurgery, Adnan Menderes University Medical Faculty, Aydin

    Mehmet Turgut

  2. Department of Neurosurgery, Pamukkale University Medical Faculty, Denizli

    Kadir Tahta

  3. Department of Neurosurgery, Hacettepe University Medical Faculty, Ankara, Turkey

    Osman E. Özcan

  4. Department of Pathology, Hacettepe University Medical Faculty, Ankara, Turkey

    Behsan Önol

  5. Cumhuriyet Mahallesi Cumhuriyet Caddesi 2. Sokak, Darcan Apartmani No:1/6, TR-09020, Aydin, Turkey

    Mehmet Turgut

Authors
  1. Mehmet Turgut
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  2. Kadir Tahta
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  3. Osman E. Özcan
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  4. Behsan Önol
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Turgut, M., Tahta, K., Özcan, O.E. et al. The treatement of cerebral oligodendrogliomas with particular reference to features indicating malignancy: Report of seventy-seven cases. Neurosurg. Rev. 21, 138–146 (1998). https://doi.org/10.1007/BF02389319

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  • DOI: https://doi.org/10.1007/BF02389319

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