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Sixty-eight out of 149 chronic hemodialysis patients without recent administration of the active vitamin D did not actually show the secondary hyperparathyroidism evaluating by the intact PTH levels. High incidence of diabetes mellitus was recognized in the patients with the normal or low intact PTH level. The 33 patients could be divided into two groups, the responders and nonresponders, in accordance with the intact PTH response to calcium-free hemodialysis technique. The basal C-PTH and intact PTH of the responders were higher than those of the nonresponders, however the levels of plasma ferritin and aluminium, and desferrioxamine loading tests did not show any difference between them. Number of Diabetic patient also distributed evenly between two groups.
Diabetes mellitus, aluminium intoxication and iron overload were not fully responsible for the poor secretion of intact PTH in the chronic hemodialysis patients.
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Suzuki, M., Hirasawa, Y., Center, K. et al. Decreased parathyroid hormone secretion in chronic hemodialysis patients without active vitamin D treatment. J Bone Miner Metab 9, 45–48 (1991). https://doi.org/10.1007/BF02374906
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DOI: https://doi.org/10.1007/BF02374906