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Anomalous oxygen uptake by flowing blood

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Abstract

It is found that oxygen uptake by whole blood flowing in rectangular channels greatly excedes theoretical predictions, despite the fact that such predictions are accurate when used with other channel geometries. An “optimum” rectangular channel aspect ratio for oxygen uptake improvement, relative to theory, is found and the possible use of the anomalous gas transfer in membrane oxygenator construction is indicated.

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References

  • Buckles, R. G., Merrill, E. W. andGilliland, E. R., An analysis of oxygen absorption in a tubular membrane oxygenator.American Institute of Chemical Engineers Journal, 1968,14, 703.

    CAS  Google Scholar 

  • Coleman, B. D., Markovitz, H., andNoll, W.,Viscometric flows of non-Newtonian fluids, New York: Springer Verlag, 1966, Chapter 5.

    Google Scholar 

  • Drake, R. F.,et al., Implantable fuel cell for an artificial heart, Report #PB 182591, Clearinghouse for Federal Scientific and Technical Information, 1968.

  • Green, A. E., andRivlin, R. A., Steady flow of non-Newtonian fluids through tubes,Quarterly of Applied Mathematics, 1956,14, 229.

    Google Scholar 

  • Goldstick, T. K., Diffusion of oxygen in protein solutions, Ph.D. Dissertation, University of California at Berkeley, 1966.

  • Happel, J., andBrenner, H.,Low Reynolds number hydrodynamics, Englewood Cliffs, N.J.: Prentice Hall, 1965.

    Google Scholar 

  • Keller, K., Development of a Couette oxygenator. InArtificial heart program conference proceedings, Washington, D. C., June 1969, Chapter 34.

  • Kogan, E., and Merchuk, J. C., Transfer of O2 and CO2 in a membrane artificial lung. II. Experimental. InFirst Pacific chemical engineering congress, Kyoto, 1972. Part I, p. 159.

  • Merrill, E. W., Benis, A. M., Gilliland, E. R., Sherwood, T. K., andSalzman, E. W. Pressure-flow relations of human blood in hollow fibers at low flow rates.Journal of Applied Physiology, 1965,20, 954.

    CAS  PubMed  Google Scholar 

  • Perry, J. A.,Chemical engineers' handbook. New York: McGraw Hill, 1963.

    Google Scholar 

  • Rouse, H. (Ed.),Advanced mechanics of fluids. New York: Wiley, 1963.

    Google Scholar 

  • Schlichting, H.,Boundary layer theory, New York: McGraw-Hill, 1960.

    Google Scholar 

  • Sosa, O., and Merchuk, J. C., Transfer of O2 and CO2 in a membrane artificial lung. I. Theoretical. InFirst Pacific chemical engineering congress, Kyoto, 1972, Part I, p. 151.

  • Spaeth, E. E., The convective diffusion of oxygen, carbon dioxide and inert gas in blood, Report from W. M. Keck Laboratory of Environmental Health Engineering, California Institute of Technology, 1967.

  • Stein, T. R., Augmented diffusion of oxygen, Ph.D. Dissertation, University of Minnesota, 1968.

  • Villaroel, F., Mathematical modeling of respiratory gas exchange in capillary tube oxygenators with steady blood flow, Document #HDL-TM-70-18, U. S. Army, Harry Diamond Laboratories, 1970.

  • Weissman, M. H., andMockros, L. F., Oxygen and carbon dioxide transfer in membrane oxygenators.Medical and Biological Engineering, 1969,7, 169.

    CAS  Google Scholar 

  • Weissman, M. H., andMockros, L. F., Oxygen transfer to blood flowing in round tubes,Journal of the Engineering Mechanics Division, Proceedings of the American Society of Civil Engineers, 1967,93, 225.

    Google Scholar 

  • Weissman M. H., Factors determining transfer rates in membrane oxygenators, Preprint 25d,American Institute of Chemical Engineers 72nd National Meeting, St. Louis, 1972.

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Weissman, M.H. Anomalous oxygen uptake by flowing blood. Annals of Biomedical Engineering 1, 468–480 (1973). https://doi.org/10.1007/BF02367270

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  • DOI: https://doi.org/10.1007/BF02367270

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