Abstract
The localization of sialic acid in the trabecular meshworks of the normal human primary open-angle (POAG), congenital and juvenile glaucomatous eyes was investigated using both an electron microscope and lectins specifically binding with sialic acid. Sialic acid was always localized in fine fibrils lying underneath the canal wall and around collagen fibrils of the whole trabecular tissue. In both congenital and juvenile glaucoma, sialic acid was detected not only in the fine fibrils but also in the basement membrane-like materials in compact tissue present 3 μm underneath the canal wall. Sialated glycoprotein appears to play an important role in the pathogenesis of both diseases.
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References
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Nagata, S., Umihira, J., Nohara, M. et al. Localization of sialic acid in the human trabecular meshwork. Med Electron Microsc 27, 289–291 (1994). https://doi.org/10.1007/BF02349677
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DOI: https://doi.org/10.1007/BF02349677