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Peripheral pharmacokinetic parameters of levodopa/carbidopa and the on-off phenomenon in parkinsonian patients

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Abstract

The principal peripheral pharmacokinetic parameters of the levodopa/carbidopa association were investigated in 11 healthy volunteers and in 16 patients at various stages of Parkinson disease, with and without the on-off phenomenon. After oral administration of a standard dose of drug (levodopa 250 mg + carbidopa 25 mg) the peak plasma concentrations, peak onset time and area under the curve/time proved to be similar across the groups. There was no difference in peripheral pharmacokinetics of the association between parkinsonian patients with swings in response and those without.

Sommario

I principali parametri farmacocinetici periferici della associazione levodopa/carbidopa sono stati studiati in 11 volontari sani ed in 16 pazienti affetti da morbo di Parkinson in differenti stadi di malattia, con e senza fluttuazioni delle performances motorie.

Dopo somministrazione per via orale di una dose standard del farmaco (levodopa 250 mg., carbidopa 25 mg.), i valori della concentrazione plasmatica massima, del tempo di comparsa del picco e dell'area sotto la curva concentrazione/tempo sono risultati simili in tutti i gruppi esaminati.

La farmacocinetica periferica dell'associazione levodopa/carbidopa non è risultata essere differente nei parkinsoniani che presentavano delle fluttuazioni delle performances motorie in confronto ai pazienti con stabile risposta clinica alla terapia.

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Rainero, I., Gilli, M., De Gennaro, T. et al. Peripheral pharmacokinetic parameters of levodopa/carbidopa and the on-off phenomenon in parkinsonian patients. Ital J Neuro Sci 9, 255–259 (1988). https://doi.org/10.1007/BF02334049

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  • DOI: https://doi.org/10.1007/BF02334049

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