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Sympathoadrenal activation and the dumping syndrome after gastric surgery

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Abstract

Dumping symptoms suggest concomitant sympathoadrenal activation. To evaluate the relation between dumping symptoms and postprandial plasma catecholamine changes, standardized dumping-provocation tests with use of oral glucose were performed for 16 gastric surgery patients with dumping, for 14 gastric surgery patients without dumping, and for 14 healthy control patients. Early dumping symptoms were present for all patients with dumping, and late symptoms developed in three patients with dumping after glucose ingestion. Patients without dumping and healthy control patients had slight complaints or no complains. Systolic and diastolic blood pressure remained unaffected for the three groups. Positive breath-hydrogen tests, heart rate increments, and reactive plasma glucose decrements were present for patients with dumping and for patients without dumping, but not for control patients. Plasma noradrenaline and adrenaline increased for patients with dumping and for patients without dumping, but not for control patients. The noradrenaline increment was higher for patients with dumping (98%) than for patients without dumping (78%; p<0.05). The noradrenaline increment was related to the dumping score and to the heart rate increment for the first hour after glucose ingestion, whereas the adrenaline increment was related to the plasma glucose decrement for the third hour. Therefore, dumping symptoms clearly are accompanied by postprandial sympathoadrenal activation, but sympathoadrenal activation cannot account completely for development of dumping symptoms.

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Authors and Affiliations

  1. Department of Medicine, Division of General Internal Medicine, University Medical Centre Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands

    D. Jannet Mehagnoul-Schipper M.D. & Jacques W. M. Lenders M.D., Ph.D.

  2. Department of Chemical Endocrinology, University Medical Centre Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands

    Jacques J. Willemsen B.A.

  3. Department of Medicine, Division of Gastroenterology, University Medical Centre Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands

    Wim P. M. Hopman M.D., Ph.D.

Authors
  1. D. Jannet Mehagnoul-Schipper M.D.
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  2. Jacques W. M. Lenders M.D., Ph.D.
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  3. Jacques J. Willemsen B.A.
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  4. Wim P. M. Hopman M.D., Ph.D.
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Correspondence to Jacques W. M. Lenders M.D., Ph.D..

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Jannet Mehagnoul-Schipper, D., Lenders, J.W.M., Willemsen, J.J. et al. Sympathoadrenal activation and the dumping syndrome after gastric surgery. Clinical Autonomic Research 10, 301–308 (2000). https://doi.org/10.1007/BF02281113

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  • DOI: https://doi.org/10.1007/BF02281113

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