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Recent advances in understanding thyroid hormone receptor coregulators

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Journal of Biomedical Science

Abstract

Thyroid hormones (L-triiodothyronine, T3;L-tetraiodothyronine, T4) regulate normal cellular growth and development, and general metabolism as well. Their various actions are mediated by the thyroid hormone receptor, a ligand-dependent transcriptional factor belonging to the nuclear hormone receptor superfamily. The recent discovery of coregulators (coativators, corepressors, and cointegrators) has greatly enhanced our understanding of thyroid hormone receptor functions. Hence we review and discuss, in brief, the potential role of thyroid hormone receptor coregulators involved in diverse cellular activities.

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Authors and Affiliations

  1. Institute of Biotechnology and Department of Life Science, National Dong Hwa University, Hualien, Taiwan, ROC

    Han-Jung Lee

  2. Molecular and Cellular Endocrinology Branch, NIDDK, NIH, 20892, Bethesda, MD, USA

    Paul M. Yen

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Lee, HJ., Yen, P.M. Recent advances in understanding thyroid hormone receptor coregulators. J Biomed Sci 6, 71–78 (1999). https://doi.org/10.1007/BF02256437

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  • DOI: https://doi.org/10.1007/BF02256437

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