Abstract
The effects of the antidepressant trazodone on clinical state and on EEG sleep in eight outpatients with a major depressive disorder were investigated in a single blind study. A medication period of 5 weeks was preceded and followed by one week placebo treatment. Five subjects showed a positive treatment response. Trazodone did not influence sleep continuity and slow wave sleep, but did suppress REM sleep significantly. A significant increase of REM sleep latency was also found. These results are in contrast with earlier reports on trazodone's effects on EEG sleep but are in accordance with the general finding that antidepressants influence REM sleep characteristics without necessarily affecting sleep continuity.
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References
American Psychiatric Association: diagnostic and statistical manual of mental disorders (DSM-III-R) (1987), 3rd revised edn. APA, Washington DC
Beersma DGM, Dijk DJ, Blok CGH, Everhardus I (1990) REM sleep deprivation during 5 hours leads to an immediate REM sleep rebound and to suppression of non-REM sleep intensity. Electroencephalogr Clin Neurophysiol 76:114–122
Borbély AA (1987) The S-Deficiency hypothesis of depression and the two-process model of sleep regulation. Pharmacopsychiatry 20:23–29
Borbély AA, Baumann F, Brandeis D, Strauch I, Lehmann D (1981) Sleep deprivation: effect on sleep stages and EEG power density in man. Electroencephalogr Clin Neurophysiol 51:483–493
Coble PA, Kupfer DJ, Shaw DH (1981) Distribution of REM latency in depression. Biol Psychiatry 16:453–466
Dijk DJ, Strijkstra A, Daan S, Beersma DGM, van den Hoofdakker RH (1991) Effect of clomipramine on sleep and EEG power spectra in the diurnal rodentEutamias Sibiricus. Psychopharmacology 103:375–379
Elsenga S (1988) Een zelfbeoordelingsschaal voor depressie. T voor Psychiatrie 30:114–126
Gillin JC, Borbély AA (1985) Sleep, a neurobiological window on affective disorders. TINS 8:573–542
Gillin JC, Kripke DF, Risch SC, Schuckit M (1989) Slow wave sleep: relationship to primary alcoholism and to sleep deprivation in depression. In: Wauquier A, Dubovic C, Radulovacki M (eds) Slow wave sleep. Raven Press, New York, pp 141–153
Hamilton M (1967) Development of a rating scale for primary depressive illness. Br J Soc Clin Psychiatry 16:278–296
Montgomery J, Oswald I, Morgan K (1983) Trazodone enhances sleep in subjective quality but not objective duration. J Clin Pharmacol 16:139–144
Mouret J, Lemoine P, Minuit MP, Benkelfat C, Renardet M (1988) Effects of trazodone on the sleep of depressed subjects, a polygraphic study. Psychopharmacology 95:S37-S43
Mulder-Hajonides van der Meulen WREH (1981) Measurement of subjective sleep quality. In: Proceedings of the European Sleep Congress, Amsterdam, The Netherlands
Nicholson AN, Bradley CM, Pascoe PE (1989) Medications: effect on sleep and wakefulness. In: Kryger M, Roth T, Dement W (eds) Principles and practice of sleep medicine. WB Saunders, Philadelphia, pp 228–236
O'Brien RG, Kister Kaiser M (1985) MANOVA method for analyzing repeated measures designs: an extensive primer. Psychol Bull 97:316–333
Rechtschaffen A, Kales A (1968) A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. UCLA Brain Information Service Institute, Los Angeles
Vogel GW (1983) Evidence for REM sleep deprivation as the mechanism of action of antidepressant drugs. Prog Neuropharmacol Biol Psychiatry 7:343–349
Vogel GW, Buffenstein A, Minter K, Hennessey A (1990) Drug effects on REM sleep and on endogenous depression. Neurosci Biobehav Rev 14:49–63
Ware JC, Pittard JT (1990) Increased deep sleep after trazodone use: a double-blind placebo-controlled study in healthy young adults. J Clin Psychiatry 519 [suppl]:18–22
Zerssen D von (1976) Die Befindlichkeitsskala. Manual Beltz, Weinheim
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van Bemmel, A.L., Havermans, R.G. & van Diest, R. Effects of trazodone on EEG sleep and clinical state in major depression. Psychopharmacology 107, 569–574 (1992). https://doi.org/10.1007/BF02245272
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DOI: https://doi.org/10.1007/BF02245272