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Tritiated digoxin XVI

Gastric absorption

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The American Journal of Digestive Diseases Aims and scope Submit manuscript

Abstract

The sites and mechanisms of digoxin absorption in man are unknown. We have studied the fate of digoxin in the stomach by adding3H digoxin to an aqueous meal of 10% glucose and phenol red. The human stomach absorbed3H digoxin which was not changed by gastric digestion. This process appeared to contribute to the entry of tritium radioactivity into the serum within 5 minutes after intragastric administration. Gastric absorption was reduced in the presence of gastritis or gastric ulcer. Although 9 of 13 patients exhibited gastric absorption of3H digoxin, the stomach did not appear to be a major site of absorption in these studies.

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References

  1. Hunt JN: The inhibitory action of sucrose on gastric digestive activity in patients with peptic ulcer. Guy's Hosp Rep 103:161–173, 1954

    Google Scholar 

  2. Doherty JE, Perkins WH, Mitchell GK: Tritiated digoxin studies in human subjects. Arch Intern Med 108:531–539, 1961

    Google Scholar 

  3. Cooke AR, Birchall A: Absorption of ethanol from the stomach. Gastroenterology 57:269–272, 1969

    Google Scholar 

  4. Cooke AR, Hunt JN: Absorption of acetylsalicylic acid from unbuffered and buffered gastric contents. Amer J Dig Dis 15:95–102, 1970

    Google Scholar 

  5. Davenport HW: Ethanol damage to canine oxyntic glandular mucosa. Proc Soc Exp Biol Med 126:657–662, 1967

    Google Scholar 

  6. Doherty JE: The distribution and concentration of tritiated digoxin in human tissues. Ann Intern Med 66:116–124, 1967

    Google Scholar 

  7. Jelliffe RW: Personal communication

  8. Rhodes T, Bernardo DE, Phillips SF, et al: Increased reflux of bile into the stomach in patients with gastric ulcer. Gastroenterology 57:241–252, 1969

    Google Scholar 

  9. Hunt JN, Spurrell WR: The pattern of emptying of the human stomach. J Physiol 113:157, 1951

    Google Scholar 

  10. Greenberger NJ, MacDermott RP, Martin JF, et al: Intestinal absorption of six tritium-labeled digitalis glycosides in rats and guinea pigs. J Pharmacol Exp Ther 167:265–273, 1969

    Google Scholar 

  11. Truelove SC, Reynell PC: Diseases of the Digestive System. Philadelphia, FA Davis and Co, 1963, p 132

    Google Scholar 

  12. Hunt JN, Pathak JD: The osmotic effects of some simple molecules and ions on gastric emptying. J Physiol 154:254, 1960

    Google Scholar 

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Authors and Affiliations

  1. From the University of Arkansas School of Medicine, and Veterans Administration Hospital, Little Rock, Ark

    William H. Hall MD & James E. Doherty MD

Authors
  1. William H. Hall MD
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  2. James E. Doherty MD
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Additional information

Supported in part by USPHS Research Grant HE 06642-07, and Burroughs-Wellcome and Co, Inc. Tuckahoe, NY.

The authors wish to thank Jacquelyn Gammill, BS, MT (ASCP) and Joyce Sherwood, BS, MT (ASCP) for their technical assistance.

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Hall, W.H., Doherty, J.E. Tritiated digoxin XVI. Digest Dis Sci 16, 903–908 (1971). https://doi.org/10.1007/BF02238171

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  • DOI: https://doi.org/10.1007/BF02238171

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