Abstract
Myoelectric activity of the duodenum and small intestine of 7 dogs was studied over a period of 4 months using chronically implanted platinum electrodes. Secretin, 1 unit/kg body weight, reduced the incidence of bursts of action potentials without significant effect on the frequency or velocity of the pacesetter potential (slow wave). Inhibition of action potentials was greater in the duodenum and jejunum than in the ileum in all dogs studied. It is concluded that a gradient of diminishing inhibitory action of secretin on action potentials, and therefore on motor activity, extends distally throughout the small intestine.
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References
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Supported in part by Research Grant AM-2015 from NIH, US Public Health Service.
Read at the meeting of the American College of Surgeons, San Francisco, Oct 6–10, 1969.
The authors thank Mr. J. C. Miller for technical assistance and Dr. W. F. Taylor and Mrs. Pamela Doctor of the Section of Medical Statistics, Epidemiology and Population Genetics, Mayo Clinic, for aiding in the statistical analysis of the results.
Address for reprint requests: Section of Publications, Mayo Clinic, Rochester, Minn 55901.
Recipient of a travelling fellowship from the Medical Research Council of Great Britain.
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Hermon-Taylor, J., Code, C.F. Effect of secretin on small bowel myoelectric activity of conscious healthy dogs. Digest Dis Sci 15, 545–550 (1970). https://doi.org/10.1007/BF02238115
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DOI: https://doi.org/10.1007/BF02238115