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Dubin-Johnson syndrome in immature sheep

  • Comparative Gastroenterology
  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

Abstract

Hyperbilirubinemia and a delayed plasma clearance of sulfobromophthalein was observed in neonatal mutant lambs possessing a syndrome similar to Dubin-Johnson syndrome in man. Characteristic discoloration of the liver due to hepatocellular pigmentation was not discernible at birth when examined by electron and light microscopy. The livers of 2 mutants were first observed to be grossly discolored owing to pigment accumulation at 7 and 11 weeks of age, respectively. The brownish-black pigment was primarily found in the pericanalicular dense bodies of centrilobular hepatocytes.

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References

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Authors and Affiliations

  1. From the Department of Physiological Sciences, Kansas State University, Manhattan, Kan.

    C. E. Cornelius D.V.M., Ph.D., B. I. Osburn D.V.M., Ph.D., R. R. Gronwall D.V.M., Ph.D. & G. H. Cardinet III D.V.M., Ph.D.

  2. the Department of Pathology, Oklahoma State University, Stillwater, Okla.

    C. E. Cornelius D.V.M., Ph.D., B. I. Osburn D.V.M., Ph.D., R. R. Gronwall D.V.M., Ph.D. & G. H. Cardinet III D.V.M., Ph.D.

Authors
  1. C. E. Cornelius D.V.M., Ph.D.
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  2. B. I. Osburn D.V.M., Ph.D.
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  3. R. R. Gronwall D.V.M., Ph.D.
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  4. G. H. Cardinet III D.V.M., Ph.D.
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Supported in part by U. S. Public Health Service Grant AM 11384-01.

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Cornelius, C.E., Osburn, B.I., Gronwall, R.R. et al. Dubin-Johnson syndrome in immature sheep. Digest Dis Sci 13, 1072–1076 (1968). https://doi.org/10.1007/BF02233553

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  • DOI: https://doi.org/10.1007/BF02233553

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