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Anticholinergic drug action on pancreatic exocrine outflow in man and dog

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Summary

The endogenous secretin mechanism in dogs and in man is very sensitive to low concentrations of anticholinergic drugs. The release of secretin may be blocked by very small doses of these anticholinergic drugs, but once secretin gets into the bloodstream, its action can only be partially blocked by very large concentrations of the anticholinergic drugs.

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Authors and Affiliations

  1. From the Department of Anatomy, College of Basic Medical Sciences and Departments of Medicine (Division of Gastroenterology) and Surgery, University of Tennessee Medical Units, Memphis, Tenn

    H. Schapiro Ph.D., L. D. Wruble M.D., J. W. Estes M.D., R. Sherman M.D. & L. G. Britt M.D.

Authors
  1. H. Schapiro Ph.D.
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  2. L. D. Wruble M.D.
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  3. J. W. Estes M.D.
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  4. R. Sherman M.D.
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  5. L. G. Britt M.D.
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Additional information

The authors wish to thank Mr. T. L. Willis for technical assistance and Mr. D. L. House, Jr., M.S.L.S. (supported by USPHS Grant LM-00102) for library assistance.

Supported in part by a grant from the Licensed Beverage Industries.

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Schapiro, H., Wruble, L.D., Estes, J.W. et al. Anticholinergic drug action on pancreatic exocrine outflow in man and dog. Digest Dis Sci 13, 608–614 (1968). https://doi.org/10.1007/BF02232967

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