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Effect of meprobamate on gastric activity

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Summary

We have studied the effect of meprobamate on gastic secretion, giving 7 patients 600 mg. of the drug by mouth in a single dose and measuring in the following 2 hours, volume, free acidity, and total acidity of the gastric juice withdrawn by aspiration. Results obtained from the same patients after administration of a substance whose excitosecretory effect is nil, showed no difference.

In another group of 13 patients, the fractional method of gastric analysis (Katsch-Kalk) was used and repeated 2 days after every patient had been given a daily dose of 1.2 gm. of meprobamate by mouth. In this series, as in the other, no noteworthy modification in the acidity curves was observed.

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Authors and Affiliations

  1. From the Department of Internal Medicine, Escola Paulista de Medicina, São Paulo, Brazil

    F. Cintra do Prado M.D., Wladimir Gomes Ferraz M.D., Edmir Rodrigues Lopes M.D. & Bárbara S. Metzner M.D.

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  1. F. Cintra do Prado M.D.
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  2. Wladimir Gomes Ferraz M.D.
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  3. Edmir Rodrigues Lopes M.D.
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  4. Bárbara S. Metzner M.D.
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Cintra do Prado, F., Gomes Ferraz, W., Rodrigues Lopes, E. et al. Effect of meprobamate on gastric activity. Digest Dis Sci 6, 833–840 (1961). https://doi.org/10.1007/BF02231080

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  • DOI: https://doi.org/10.1007/BF02231080

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