Abstract
A retrospective survey on 66 adults with epilepsy who received multiple drug therapy after the failure of single drugs showed: a reduction of seizure frequency of 75% or more in 16.5%, no change in 67% and an increase in seizure frequency of 100% or more in 16.5%. Multiple drug therapy is of limited value in severe epilepsies.
Sommario
Lo studio comprende una analisi retrospettica su 66 pazienti adulti con epilessia che, dopo non aver ottenuto la scomparsa completa delle crisi con differenti monoterapie, hanno intrapreso un trattamento combinato. Nel 16,5% dei casi si è osservata, con l'introduzione della politerapia, una riduzione delle crisi del 75% ed oltre; nel 67% non si è assistito ad alcuna modificazione della frequenza critica, mentre questa è aumentata del 100% ed oltre in un altro 16,5% dei casi. La politerapia sembra essere di valore limitato nei casi di epilessia farmaco-resistente.
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Cornaggia, C., Canevini, M.P., Giuccioli, D. et al. Monotherapy and polytherapy for intractable epilepsies. Ital J Neuro Sci 6, 201–205 (1985). https://doi.org/10.1007/BF02229193
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DOI: https://doi.org/10.1007/BF02229193