Skip to main content
SpringerLink
Log in

N-adamantyl derivatives of arylamides of α-azacycloalkanecarboxylic acids and their topical anesthetic activity

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Abstract

A series of arylamides of α-[N-adamantylpyrrolidyl-(or piperidyl)]carboxylic acids was obtained by reacting 1-(or 2-)aminoadamantanes with arylamides of α,Ω-dihalovaleric (or caproic) acid. The compounds exhibited a pronounced anesthetic activity in experiments.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. D. Tullar,J. Med. Chem.,14, 891 - 894 (1971).

    Article  PubMed  Google Scholar 

  2. N. T. Pryanishnikova, L. S. Lebedeva, et al.,Farmakol. Toksikol., No. 3, 288 - 291 (1972).

    Google Scholar 

  3. A. M. Likhosherstov, N. T. Pryanishnikova, A. S. Lebedeva, et al.,Khim.-Farm. Zh.,4(9), 27 - 31 (1970).

    Google Scholar 

  4. G. Alerg, V. G. Dhuner, and S. Sydnes,Acta Pharmacol. (Kbh),41, 432 - 443 (1977).

    Google Scholar 

  5. R. T. Rapalg, R. G. Edie, P. Korzekwa, et al.,J. Med. Chem.,11, 1079 - 1082 (1968).

    Article  PubMed  Google Scholar 

  6. D. A. Kharkevich and A. P. Skoldinov,Dokl. Akad. Nauk SSSR,198(4), 984 - 987 (1971).

    Google Scholar 

  7. N. V. Klimova, L. N. Lavrova, N. M. Zaitseva, et al.,Khim.-Farm. Zh.,20(7), 809 - 814 (1986).

    Google Scholar 

  8. N. T. Pryanishnikova, A. S. Lebedeva, A. M. Likhosherstov, et al.,Khim.-Farm. Zh.,5(1), 7 - 9 (1971).

    Google Scholar 

  9. J. Regnier,C. R. Acad. Sci. (Paris),177, 558 - 561 (1923).

    Google Scholar 

  10. C. Bianchi,Br. J. Pharmacol.,11, 104 - 106 (1956).

    Google Scholar 

  11. B. Behrens,Arch. Exp. Path. Pharmakol.,140, 237 - 238 (1929).

    Article  Google Scholar 

  12. J. Setnicar,Arzneimittel-Forsch.,16, 623 - 628 (1966).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia

    N. I. Avdyunina, N. V. Klimova, A. S. Lebedeva, A. M. Likhosherstov, V. M. Pyatin, A. P. Skoldinov & I. V. Chernyakova

Authors
  1. N. I. Avdyunina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. V. Klimova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. S. Lebedeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. M. Likhosherstov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. M. Pyatin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. P. Skoldinov
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. I. V. Chernyakova
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Avdyunina, N.I., Klimova, N.V., Lebedeva, A.S. et al. N-adamantyl derivatives of arylamides of α-azacycloalkanecarboxylic acids and their topical anesthetic activity. Pharm Chem J 29, 115–118 (1995). https://doi.org/10.1007/BF02226522

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02226522

Keywords

Search

Navigation