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Synthesis and biological activity of substituted 7-aza-8-aza(oxa)-bicyclo[4.3.0]-6,9-nonadienes

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Abstract

Hydroxylamine- and hydrazine-induced heterocyclization of readily available 5-hydroxy-2.4-diacetyl-5-methyl-3R-cyclohexanones (R = methyl, phenyl, m-nitrophenyl, α-furyl) yielded 6-acetyl-5-hydroxy-5.9-dimethyl-7R-1-aza(oxa)-2-azabicyclo[4.3.0]-2,8-nonadienes (R = methyl, phenyl,m-nitrophenyl. α-furyl). The biological activity of the latter was tested using theEscherichia coli phage T4, and was also tested on a stored lyophilized culture ofYersinia pestis EU.

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References

  1. B. Prameela, E. Rajanarender, J. N. Shoolery, et al.,Ind. J. Chem.,B24(12), 1255–1258 (1985).

    Google Scholar 

  2. Shri Hiwas, Shiv Rumar, and A. P. Bhaduri,Indian J. Chem.,B23(7), 599–602 (1985).

    Google Scholar 

  3. J. L. Finar,J. Chem. Soc., No. 2, 674–679 (1961).

    Google Scholar 

  4. L. M. Fonshtein, T. I. Suraikina, E. K. Tal', and Yu. Shch. Moshkovskii,Genetika,11(7), 128–133 (1975).

    Google Scholar 

  5. Procedure for Determining the Thermal Stability of Live Dry Vaccines and Predicting Their Viability in Storage (Procedural Recommendations) [in Russian], Stavropol' (1985).

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Authors and Affiliations

  1. Russian Antiplague Research Institute “Mikrob”, Saratov University, Saratov, Russia

    N. O. Smirnova, O. P. Plotnikov, N. A. Vinogradova, V. V. Sorokin & A. P. Kriven'ko

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  1. N. O. Smirnova
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  2. O. P. Plotnikov
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  3. N. A. Vinogradova
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  4. V. V. Sorokin
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  5. A. P. Kriven'ko
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Smirnova, N.O., Plotnikov, O.P., Vinogradova, N.A. et al. Synthesis and biological activity of substituted 7-aza-8-aza(oxa)-bicyclo[4.3.0]-6,9-nonadienes. Pharm Chem J 29, 49–50 (1995). https://doi.org/10.1007/BF02219464

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  • DOI: https://doi.org/10.1007/BF02219464

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