Summary
Production of interleukin-1 (IL-1) by glass-adherent monocytes from 18 patients with systemic lupus erythematosus (SLE) was measured. Patients were divided into three groups according to disease activity. A deficient production of IL-1 was found in monocytes of SLE patients both without stimulation and after stimulation with 5 μg of lipopolysaccharide. The decreased production correlated with the degree of disease. Addition of phorbol myristate acetate to monocytes caused only partial normalization of the decreased IL-1 production. The IL-1 deficiency in SLE is postulated to be a part of complex abnormalities of cell-mediated immunity in this disease.
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Sierakowski, S., Kucharz, E.J., Lightfoot, R.W. et al. Interleukin-1-production by monocytes from patients with systemic lupus erythematosus. Clin Rheumatol 6, 403–407 (1987). https://doi.org/10.1007/BF02206840
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DOI: https://doi.org/10.1007/BF02206840