Summary:
The condition of coronary arteries and aortic valves was studied in 552 Syrian hamsters belonging to a single family subjected to high endogamous pressure. The study was carried out using a corrosion-cast technique. In 178 hamsters the aortic valve was bicuspid. In 138 specimens, 54 of them with normal aortic valves and 84 with bicuspid aortic valves, anomalies in the origin of the coronary arteries could be classified in three morphologic types: left coronary artery from the pulmonary trunk (36 cases); single right coronary artery (84 cases); left coronary artery from the dorsal aortic sinus (18 cases). Results of a ξ2 contingency test show that the frequency of left coronary artery from the pulmonary trunk and single right coronary artery significantly increases when the aortic valve is bicuspid. The present findings suggest that there is a developmental complex consisting of bicuspid aortic valve and anomalous origin of the coronary arteries.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Arqué JM, Cruz V, Rosado LM, Sans-Coma V (1986) Congenital anomalies of the coronary arteries in rodents. Am J Cardiol 57:498–499
Arqué JM, Sans-Coma V, Durán AC, Cardo M (1989) Origen anómalo de la arteria coronaria izquierda en el tronco pulmonar y su relation con otras anomalfas coronarias primarias: estudio experimental. Rev Esp Cardiol 42:399–409
Bhattacharyya GK, Johnson RA (1977) Statistical concepts and methods. John Wiley & Sons, New York Chichester Brisbane Toronto Singapore, pp 434–435
Click RL, Spittell JA, Puga FJ (1988) Chest pain in a young woman. Mayo Clin Proc 63:368–372
Durán AC, Arqué JM, Cardo M, Sans-Coma V (1988) Descripción morfológica de una nueva anomalfa arterial coronaria en el hamster sirio Mesocricetus auratus (Waterhouse, 1839); interpretación genética y filogenética. Mist Zool 12:329–338
Higgins CB, Wexler L (1975) Reversal dominance of the coronary arterial system in isolated aortic stenosis and bicuspid aortic valve. Circulation 52:292–296
Hillestad L, Eie H (1971) Single coronary artery. A report of three cases. Acta med stand 189:409–413
Hurle JM, Colvée E, Blanco AM (1980) Development of mouse semilunar valves. Anat Embryol 160:83–91
Hutchins GM, Nazarian IH, Bulkley B (1978) Association of left dominant coronary arterial system with congenital bicuspid aortic valve. Am J Cardiol 42:57–59
Lerer PK, Edwards WD (1981) Coronary arterial anatomy in bicuspid aortic valve. Necropsy study of 100 hearts. Br Heart J 45:142–147
Roberts JT, Loube SD (1947) Congenital single coronary artery in man. Report of nine new cases, one having thrombosis with right ventricular and atrial (auricular) infarction. Am Heart J 34:188–208
Roberts WC (1986)Major anomalies of coronary arterial origin seen in adulthood. Am Heart J 111:941–963
Sans-Coma V, Arqué JM, Durán AC, Cardo M (1988) Origin of the left main coronary artery from the pulmonary trunk in the Syrian hamster. Am J Cardiol 62:159–161
Sans-Coma V, Arqué JM, Durán AC, Cardo M (1989) Anomalous origin of the coronary arteries in mammals. Zool Anz 223:254–264
Virmani R, Rogan K, Cheitlin MD (1989) Congenital coronary artery anomalies: pathologic aspects. In: Virmani R, Forman MB (eds) Nonatherosclerotic Ischemic Heart Disease. Raven Press, New York, pp 153–183
Zuber M, Wortmann J (1984) Untersuchung zur Entwicklung des Koronargefäßsystems bei der Maus. Verb Anat Ges 78:269–270
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sans-Coma, V., Arqué, J.M., Durán, A.C. et al. Coronary artery anomalies and bicuspid aortic valves in the Syrian hamster. Basic Res Cardiol 86, 148–153 (1991). https://doi.org/10.1007/BF02190547
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02190547