Summary
Familial rates of psychiatric disorders were studied in southern Sardinia and showed an increase in relatives of probands with the following research diagnostic criteria (RDC) diagnoses: normal, unipolar depression, schizoaffective depressive, schizoaffective bipolar, bipolar with mania and bipolar with hypomania. A significantly higher risk for bipolar schizoaffective disorder was observed in relatives of bipolar schizoaffectives compared with relatives of normal probands.
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Andreasen NC, Rice J, Endicott J, Coryell W, Grove WM, Reich T (1987) Familial rates of affective disorder. Arch Gen Psychiatry 44:461–469.
Angst J (1966) Zur Aetiologie und Nosologie endogener depressiver Psychosen. Springer, Berlin Heidelberg New York
Angst J, Felder W, Lohmeyer B (1979a) Schizoaffective disorders: results of a genetic investigation. I. J. Affect Dis 1: 139–153.
Angst J, Felder W, Lohmeyer B (1979b) Are schizoaffective psychoses heterogeneous? Results of a genetic investigation. II. J Affect Dis 1: 155–165
Baron M, Gruen R, Asnis L, Kane J (1982) Schizoaffective illness, schizophrenia and affective disorders: morbidity risk and genetic transmission. Acta Psychiatr Scand 65:253–262
Bocchetta A, Pedditzi M, Bernardi F, Corona R, Del Zompo M (1989) Thalassaemia minor and affective disorders. In: Stefanis CN, Soldatos CR, Rabavilas AD (eds) Psychiatry today, accomplishments and promises. VIII World Congress of Psychiatry Abstracts. Elsevier, Amsterdam, p 395
Bocchetta A, Del Zompo M, Corsini GU (1990) Glucose-6-phosphate dehydrogenase deficiency and psychoses. In: Cazzullo CL, Sacchetti E, Conte G, Invernizzi G, Vita A (eds) Plasticity and Morphology of the Central Nervous System: a Challenge for Psychiatry of the Nineties. Kluwer Academic Publisher, Dordrecht Boston London, pp 211–220
Breborowicz G, Trzebiatowska-Trzeciak O (1976) A method of testing differences in morbidity risk for affective psychoses. Acta Psychiatr Scand 54:353–358
Coryell W, Winokur G, Andreasen N (1981) The effect of case definition on affective disorder rates. Am J Psychiatry 138: 1106–1109
Coryell W, Zimmerman M (1988) The heritability of schizophrenia and schizoaffective disorder. Arch Gen Psychiatry 45:323–327
Crow TJ (1986) The continuum of psychosis and its application for the structure of the gene. Br J Psychiatry 149:419–429
Gershon ES, Mark A, Cohen M, Belizon N, Baron M, Knobe K (1975) Transmitted factors in the morbid risk of affective disorders: a controlled study. J Psychiatr Res 12: 283–299
Gershon ES, Hamovit J, Guroff JJ, Dibble E, Leckman JF, Sceery W, Targum SD, Nurnberger JI Jr, Goldin LR, Bunney WE Jr (1982) A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands. Arch Gen Psychiatry 39:1157–1167
Gershon ES, Hamovit JH, Guroff JJ, Nurnberger JI (1987) Birthcohort changes in manic and depressive disorders in relatives of bipolar and schizoaffective patients. Arch Gen Psychiatry 44:314–319
Gershon ES, Delisi LE, Hamovit J, Nurnberger JI Jr, Maxwell ME, Schreiber J, Dauphinais K, Dingman CW, Guroff JJ (1988) A controlled family study of chronic psychoses. Arch Gen Psychiatry 45:328–336
Kaij L (1967) Atypical endogenous psychosis: report on a family. Br J Psychiatry 113:415–422
Kendler KS, Gruenberg AM, Tsuang MT (1986) A DSM-III family study of nonschizophrenic psychotic disorders. Am J Psychiatry 143: 1098–1105
Klerman GL, Lavori PW, Rice J, Reich T, Endicott J, Andreasen NC, Keller MB, Hirschfield RMA (1985) Birth-cohort trends in rates of major depressive disorder among relatives of patients with affective disorder. Arch Gen Psychiatry 42:689–693
Maj M (1989) A family study of two subgroups of schizoaffective patients. Br J Psychiatry 154:640–643
Marneros A, Deister A, Rohde A (1988) Syndrome shift in the long-term course of schizoaffective disorders. Eur Arch Psychiatry Neurol Sci 238:97–104
Mendlewicz J, Linkowski P, Wilmotte J (1980) Relationship between schizoaffective illness and affective disorders or schizophrenia: morbidity risk and genetic transmission. J Affect Dis 2:289–302
Rice J, Reich T, Andreasen NC, Endicott J, Van Eerdewegh M, Fishman R, Hirschfield RMA, Klerman GL (1987) The familial transmission of bipolar illness. Arch Gen Psychiatry 44: 441–447
Tsuang MT, Dempsey GM, Dvoredsky A, Strauss A (1977) A family history study of schizoaffective disorder. Biol Psychiatry 12:331–338
Tsuang MT, Winokur G, Crowe RR (1980) Morbidity risks of schizophrenia and affective disorders among first-degree relatives of patients with schizophrenia, mania, depression and surgical conditions. Br J Psychiatry 137:497–504
Walinder J (1972) Recurrent familial psychosis of the schizoaffective type. Acta Psychiatr Scand 48:274–283
Winokur G (1984) Psychosis in bipolar and unipolar affective illness with special reference to schizo-affective disorder. Br J Psychiatry 145:236–242
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Supported by a grant from Regione Autonoma della Sardegna, Assessorato all'Igiene e Sanità
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Bocchetta, A., Bernardi, F., Garau, L. et al. Familial rates of affective illness in Sardinia with special reference to schizoaffective disorder. Eur Arch Psychiatry Clin Nuerosci 240, 16–20 (1990). https://doi.org/10.1007/BF02190087
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DOI: https://doi.org/10.1007/BF02190087