Summary
The cholinesterase-reactivating properties of N,N′-substituted bis-(4-hydroximinoformyl-pyridinium)-dibromides are described which bear in the carbonic chain between the pyridine moieties a nitrogen or oxygen atom. The introduction of oxygen into this chain increases the antidotal effects in paraoxon and isodemeton poisoning.
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References
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Hauschild, F., Maschhour, M., Schmiedel, R. et al. Neuartige N,N′-substituierte Bis-(4-hydroximinoformylpyridinium)-dihalogenide als Reaktivatoren für alkylphosphatgehemmte Cholinesterase. Experientia 19, 628 (1963). https://doi.org/10.1007/BF02151285
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DOI: https://doi.org/10.1007/BF02151285