Summary
The peptidergic innervation of the human and guinea pig uterus was studied using immunohistochemical methods. Antibodies against several peptides were applied for the PAP-technique to stain peptidergic nerves specifically. These are located in the adventitia of large uterine vessels in the myometrium and smaller vessels of the myometrium and endometrium. A differential distribution of the individual peptides was observed for VIP-IR (vasoactive intestinal polypeptide immunoreactivity), NPY-IR (neuropeptide Y), SP-IR (substance P), SOM-IR (somatostatin) and NT-IR (neurotensin) nerve fibers. Specific functional implications for these neuropetides can be derived from their histochemical location.
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Heinrich, D., Reinecke, M. & Forssmann, W.G. Peptidergic innervation of the human and guinea pig uterus. Arch. Gynecol. 237, 213–219 (1986). https://doi.org/10.1007/BF02133783
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DOI: https://doi.org/10.1007/BF02133783