Abstract
It is well known that oral administration of camostate induces hyperplasia and hypertrophy of the rat pancreas. It is not clear, however, whether pancreatic hormone and enzyme secretion are affected by camostate treatment.
In rats, daily administration of 200 mg camostate/kg b. wt for 14 days significantly increased pancreatic weight and pancreatic content of DNA, protein, amylase, lipase, trypsin and chymotrypsin, as well as the amount of insulin, glucagon and somatostatin. In the intact animal, blood glucose levels and serum concentrations of insulin and glucagon in response to an oral glucose load were not impaired after camostate treatment. In the isolated perfused pancreas, however, insulin and glucagon secretions were reduced, whereas somatostatin release was not affected. The volume of pancreatic juice produced by the unstimulated isolated perfused organ, as well as protein and enzyme secretion, were increased after camostate treatment. Likewise, the isolated perfused pancreas from camostate-treated rats secreted a larger volume of pancreatic juice and more protein in response to cholecystokinin (CCK), while enzyme secretion was affected in a non-parallel manner: amylase release was markedly reduced, lipase release was unchanged, and release of trypsin and chymotrypsin was increased.
Similar content being viewed by others
References
Schmidt, W. E., Stöckmann, F., Choudhury, A. R., Wilms, H. M., Siegel, E. G., Nustede, R., Fölsch, U. R., and Creutzfeldt, W., Digestion44 (1989) 105.
Morisset, J., Regul. Pept.10 (1984) 11.
Fölsch, U. R., Winckler, K., and Wormsley, K., Scand. J. Gastroenterol.13 (1978) 663.
Göke, B., Siegel, E. G., Stöckmann, F., Lankisch, P. G., and Creutzfeldt, W., Digestion31 (1985) 128.
Göke, B., Printz, H., Koop, I., Rausch, U., Richter, G., Arnold, R., and Adler, G., Pancreas1 (1986) 509.
Ihse, I., Arnesjö, B., and Lundquist, I., Scand. J. Gastroenterol.11 (1976) 529.
Keim, V., and Göke, B., Eur. J. clin. Invest.16 (1986) 519.
Solomon, T. E., Vanier, M., and Morisset, J., Am. J. Physiol.245 (1983) G99.
Wisner, J. R., McLaughlin, R. E., Rich, K. A., Ozawa, S., and Renner, I. G., Gastroenterology94 (1988) 109.
Sarfati, P. D., Genik, P., and Morisset, J., Regul. Pept.11 (1985) 263.
Müller, M. K., Goebell, H., Alfen, R., Ehlers, J., Jäger, M., and Plümpe, H., J. Nutr.118 (1988) 645.
Temler, R. S., Dormond, C. A., Simon, E., and Morel, B., J. Nutr.114 (1984) 1083.
Yamada, T., Solomon, T. E., Petersen, H., Levin, S. R., Lewin, K., and Walsh, J. H., Am. J. Physiol.238 (1980) G526.
Yamada, T., Brunstedt, J., and Solomon, T., Am. J. Physiol.244 (1983) G541.
Ziegenhorn, J., Neumann, U., Knitsch, K. W., and Zwez, W., Clin. Chem.25 (1979) 1067.
Hummel, B. C. W., Can. J. Biochem. Physiol.37 (1959) 1393.
Rick, W., and Stegbauer, H. P., in: Methoden der enzymatischen Analyse, p. 848. Ed. H. U. Bergmeier. Verlag Chemie, Weinheim 1970.
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem.193 (1951) 265.
Burton, K., Biochem. J.62 (1956) 315.
Richards, G. M., Analyt. Biochem.57 (1974) 369.
Müller, M. K., Bergmann, K., Degenhardt, H., Klöppel, G., Löhr, M., Coone, H., and Goebell, H., Transplantation45 (1988) 698.
Grodsky, G. M., Batts, A. A., Bennett, L. L., Vcella, C., McWilliams, N., and Smith, D., Am. J. Physiol.205 (1963) 638.
Arnesjö, B., Ihse, I., Lundquist, I., and Qvist, I., Scand. J. Gastroenterol.8 (1973) 545.
Williams, J. A., and Goldfine, I. D., Diabetes34 (1985) 980.
v. Schönfeld, J., Müller, M. K., Augustin, M., Rünzi, M., and Goebell, H., Dig. Dis. Sci.38 (1993) 28.
v. Schönfeld, J., Müller, M. K., Rünzi, M., Neisius, I., Kleimann, J., and Goebell, H., Metabolism42 (1993) 552.
Otsuki, M., and Williams, J. A., Am. J. Physiol.244 (1983) G683.
Bamba, T., Ishizuka, Y., and Hosoda, S., Dig. Dis. Sci.38 (1993) 653.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schönfeld, J.v., Rünzi, M., Goebell, H. et al. Endocrine and exocrine pancreatic function after camostate-induced growth of the organ. Experientia 51, 556–560 (1995). https://doi.org/10.1007/BF02128742
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02128742