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Cardiotonic activities of some new type of bufadienolide- and cardenolide-conjugates

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Summary

Some new type of bufadienolide-and cardenolide-conjugates, including bufotoxins and 3-sulfates recently isolated from the toad skin, were tested for their cardiotonic activities by using isolated frog hearts and guinea-pig atria. The relative potencies were obtained and reported.

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References

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This study was reported at the 49th General Meeting of the

Japanese Pharmacological Society, 31 March 1976, Osaka. The authors are grateful to Prof. T. Nambara, Pharmaceutical Institute, Tohoku University, Sendai, for his kind supply of the compounds used in this study.

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Shigei, T., Tsuru, H. & Ishikawa, N. Cardiotonic activities of some new type of bufadienolide- and cardenolide-conjugates. Experientia 33, 258–260 (1977). https://doi.org/10.1007/BF02124098

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  • DOI: https://doi.org/10.1007/BF02124098

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