Summary
Twenty-seven patients with primary or secondary amenorrhea were treated with gonadotropin releasing hormone (GnRH). They were given 20 μg of GnRH in 50 μl solution i.v. every 90 min by means of a peristaltic pump (Zyklomat, Ferring GmbH, Kiel). Two days after a rise in basal body temperature and when a ferning test on cervical mucus was negative the Zyklomat was removed and injections of hCG (2,500 IU) were given on alternate days until three injections had been administered. Ovulation occurred in 32 out of 40 treatment cycles and 11 patients conceived. Three of them miscarried at 6, 8, and 15 weeks of gestation. There were no severe complications of treatment and we did not encounter ovarian hyperstimulation and multiple pregnancy.
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References
Keogh EJ, Mallal SA, Giles PFH, Evans DV (1981) Ovulation induction with intermittent subcutaneous LHRH. Lancet 1: 147
Knobil E (1980) The neuroendocrine control of the menstrual cycle. Recent Prog Horm Res 36: 53–88
Leyendecker G, Wildt L (1981) Chronisch-intermittierende Gabe von GnRH. Ein Beitrag zur Physiologie und Pathophysiologie der endokrinen Regulation des menstruellen Zyklus sowie ein neues Verfahren zur Ovulationsauslösung bei hypothalamischer Amenorrhoe. Therapiewoche 31: 6711–6726
Leyendecker G, Wildt L, Hansmann M (1980) Pregnancies following chronic intermittent (pulsatile) administration of GnRH by means of a portable pump (Zyklomat) — a new approach to the treatment of infertility in hypothalamic amenorrhea. J Clin Endocrinol Metab 51: 1214–1216
Reid RL, Leopold GR, Yen SSC (1981) Induction of ovulation and pregnancy with pulsatile luteinizing hormone releasing factor: Dosage and mode of delivery. Fertil Steril 36: 553–559
Shoemaker J, Simons AHM, van Osnabrugge GJC, Lugtenburg C, van Kessel H (1981) Pregnancy after prolonged pulsatile administration of luteinizing hormone-releasing hormone in a patient with clomiphen-resistant secondary amenorrhea. J Clin Endocrinol Metab 52: 882–885
Thompson CR, Hansen LM (1970) Pergonal (Menotropins): a summary of clinical experience in the induction of ovulation an pregnancy. Fertil Steril 21: 844–853
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Dedicated to Prof. Dr. med. Josef Zander on the occasion of his 65th birthday
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Berg, D., Mickan, H., Michael, S. et al. Ovulation and pregnancy after pulsatile administration of gonadotropin releasing hormone. Arch. Gynecol. 233, 205–210 (1983). https://doi.org/10.1007/BF02114601
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DOI: https://doi.org/10.1007/BF02114601