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Preparation and biological properties of (-)- and (+)-6-hydroxydopa

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  • Pharmalogica
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Zusammenfassung

Die optischen Isomeren von 6-Hydroxydopa wurden synthetisiert und ihr Effekt auf den Katecholaminspiegel verschiedener Organe in der Ratte bestimmt. Dem (−)-Isomeren gegenüber waren Herz und Nebennieren äusserst empfindlich und im Gehirn wurde der Norepinephrinspiegel erniedrigt.

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Authors and Affiliations

  1. Roche Institute of Molecular Biology, Chemical Research Department, Hoffmann-La Roche Inc., 07110, Nutley, New Jersey, USA

    B. A. Berkowitz, S. Spector, A. Brossi, A. Focella & S. Teitel

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  1. B. A. Berkowitz
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  2. S. Spector
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  3. A. Brossi
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  4. A. Focella
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  5. S. Teitel
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Additional information

B.A.B. is the recipient of a Roche Institute of Molecular Biology postdoctoral fellowship.

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Berkowitz, B.A., Spector, S., Brossi, A. et al. Preparation and biological properties of (-)- and (+)-6-hydroxydopa. Experientia 26, 982–983 (1970). https://doi.org/10.1007/BF02114144

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  • DOI: https://doi.org/10.1007/BF02114144

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