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Hydrochloric acid hydrolysis of bromazepam. Identification and relevance of some additional products

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Abstract

WithMs andNmr spectroscopic methods the structures of three additional by-products formed in the hydrochloric acid hydrolysis of bromazepam were established. Some attention was paid to the analytical relevance of the by-products and indications are given to perform the hydrolysis in such a way that one specific product can be obtained.

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Authors and Affiliations

  1. Forensic Science Laboratory of the Ministry of Justice, Volmerlaan 17, 2288, Gd Rijswijk, The Netherlands

    M. M. A. de Bruyne & A. M. A. Verweij

  2. Laboratory of Organic Chemistry, Department of Chemical Technology, Delft University of Technology, Julianalaan 136, 2628, BL Delft, The Netherlands

    A. Sinnema

Authors
  1. M. M. A. de Bruyne
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  2. A. Sinnema
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  3. A. M. A. Verweij
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de Bruyne, M.M.A., Sinnema, A. & Verweij, A.M.A. Hydrochloric acid hydrolysis of bromazepam. Identification and relevance of some additional products. Pharmaceutisch Weekblad Scientific Edition 4, 12–15 (1982). https://doi.org/10.1007/BF02112351

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  • DOI: https://doi.org/10.1007/BF02112351

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