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Physiological role of cholecystokinin on gastric emptying and acid output in dogs

  • Esophageal, Gastric, And Duodenal Disorders
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Abstract

We investigated the physiological role of cholecystokinin (CCK) on gastric emptying and acid secretion in seven conscious dogs with gastric cannulae. Two hundred milliliters of a 4% amino acid meal was given via the cannula, and both gastric emptying and acid output were measured concurrently using a dye-dilution technique. Gastric emptying of the liquid amino acid meal was exponential, and the acid output and plasma concentrations of CCK, gastrin, and somatostatin peaked within 30 min after the meal. Intravenous infusion of CCK-8 at 28 and 56 pmol/kg/hr but not 14 pmol/kg/hr increased plasma levels of the peptide and inhibited gastric emptying as well as acid output. Plasma gastrin was not affected significantly by the CCK infusion, whereas plasma somatostatin increased significantly in response to 56 pmol/kg/hr of CCK-8. Loxiglumide, 22 µmol/kg/hr, significantly enhanced gastric emptying and augmented acid output, as well as plasma gastrin response, whereas it abolished the postprandial rise in plasma somatostain. We concluded that in dogs, CCK plays an important role in the physiologic regulation of postprandial gastric emptying of a liquid caloric meal and acid output. Its inhibitory effect on gastric acid secretion appears to be mediated, at least in part, by somatostatin.

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Authors and Affiliations

  1. From the Department of Medicine, University of Rochester Medical Center, USA

    H. -O. Jin MD, K. Y. Lee MD, PhD, T. -M. Chang PhD,  W. Y. Chey MD, DSc & A. Dubois MD, PhD

  2. Laboratory of Gastrointestinal and Liver Studies, Digestive Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, 20814-4799, Bethesda, Maryland

    H. -O. Jin MD, K. Y. Lee MD, PhD, T. -M. Chang PhD,  W. Y. Chey MD, DSc & A. Dubois MD, PhD

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  1. H. -O. Jin MD
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  2. K. Y. Lee MD, PhD
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  3. T. -M. Chang PhD
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  4. W. Y. Chey MD, DSc
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  5. A. Dubois MD, PhD
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The opinions and assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Department of Defense or the Uniformed Services University of the Health Science.

The experiments reported herein were conducted according to the principles set forth in the “Guide for the Care and Use of Laboratory Animals,” Institute of Laboratory Animal Resources, National Research Council, HHS/NIH, Publ. No. 85-23.

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Jin, H.O., Lee, K.Y., Chang, T.M. et al. Physiological role of cholecystokinin on gastric emptying and acid output in dogs. Digest Dis Sci 39, 2306–2314 (1994). https://doi.org/10.1007/BF02087643

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  • DOI: https://doi.org/10.1007/BF02087643

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