Summary
Recent studies suggested the involvement of anti-SS-A and anti-SS-B antibodies in the pathogenesis of neonatal lupus erythematosus and congenital heart block. We here describe a female neonate with lupus erythematosus, advanced atrioventricular block, and a positive test for anti-SS-A antibodies. The findings of His-bundle recordings are presented.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Akiyama Y, Mizue A, Suehiro F, Fujimoto H, Yamada T, Makino S (1982) A case of persistent congenital 2:1 A-V block associated with neonatal SLE.Ann Paediatr Jpn 28:109–114
Lane AT, Watson RM (1984) Neonatal lupus erythematosus.Am J Dis Child 138:663–666
Esscher E, Scott JS (1979) Congenital heart block and maternal systemic lupus erythematosus.Br Med J 1:1235–1238
Hardy JD, Solomon S, Banwell GS, Beach R, Wright V, Howard FM (1979) Congenital complete heart block in the newborn associated with maternal systemic lupus erythematosus and other connective tissue disorders.Arch Dis Child 54:7–13
Lockshin MD, Gibofsky A, Peebles CL, Gigli I, Fotino M, Hurwitz S (1983) Neonatal lupus erythematosus with heart block: family study of a patient with anti-SS-A and SS-B antibodies.Arthritis Rheum 26:210–213
McCue CM, Mantakas ME, Tingelstad JB, Ruddy S (1977) Congenital heart block in newborns of mothers with connective tissue disease.Circulation 56:82–90
McCuistion CH, Schoch EP Jr (1954) Possible discoid lupus erythematosus in newborn infant.Arch Dermatol Syphylis 70:782–785
Reed BR, Lee LA, Harmon C, Wolfe R, Wigins J, Peebles C, Weston WL (1983) Autoantibodies to SS-A/Ro in infants with congenital heart block.J. Pediatr 103:889–891
Scott JS, Maddison PJ, Taylor PV, Esscher E, Scott O, Skinner RD (1983) Connective tissue disease, antibodies to ribonucleoprotein, and congenital heart block.N Engl J Med 309:209–212
Litsey SE, Noonan JA, O'Connor WN, Cottrill CM, Mitchell B (1985) Maternal connective tissue disease and congenital heart block.N Engl J Med 312:98–100
Weston WL, Harmon C, Peebles C, Manchester D, Franco HL, Huff JC, Norris DA (1982) A serological marker for neonatal lupus erythematosus.Br J Dermatol 107:377–382
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shimizu, T., Ino, T., Nishimoto, K. et al. Advanced atrioventricular block in a neonate with lupus erythematosus and anti-SS-A antibodies. Pediatr Cardiol 9, 121–124 (1988). https://doi.org/10.1007/BF02083711
Issue Date:
DOI: https://doi.org/10.1007/BF02083711