Abstract
An inverse correlation between postischemic gastrointestinal motility and the length of intestinal ischemia was found in an animal model. Intestinal ischemia was caused without concurrent laparotomy and for a predetermined time period (ischemia time) by pulling on an external nylon thread that was threaded through a double-lumen catheter. This catheter was passed into the abdominal cavity to encircle the superior mesenteric artery. Gastrointestinal motility was determined by the introduction of a color-marked meal into the animal's stomach and the measurement of the proportionate length of the small bowel filled with it (transit index). This simple and reliable animal model can also be used for the evaluation of techniques and pharmacological manipulations aimed at modulation of the effects of intestinal ischemia on intestinal motility and its consequences.
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References
Berg RD: Bacterial translocation from the gastrointestinal tract. J Med 23:217–244, 1992
Guisan YJ, Hreno A, Gurd FN: Effect of acute ischemia on the motility of the small bowel in the awake dog. Eur Surg Res 7:23–33, 1975
Udassin R, Vromen A, Haskel Y: The time sequence of injury and recovery following transient reversible intestinal ischemia. J Surg Res 56:221–225, 1994
Hebra A, Brown MF, McGeehin K, Broussard D, Ross II AJ: The effects of ischemia and reperfusion on intestinal motility. J Pediatr Surg 28:362–366, 1993
Vantrappen G, Janssens J, Hellemans J, Ghoos Y: The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J Clin Invest 59:1158–1166, 1977
Rennie JA, Chritofides ND, Mitchenere P, Fletcher D, Stockley-Leathard HL, Bloom SR, Johnson AG, Harding Rains AJ: Neural and humoral factors in postoperative ileus. Br J Surg 67:694–698, 1980
Anzueto L, Benoit JN, Granger DN: A rat model for studying the intestinal circulation. Am J Physiol 246:G56-G61, 1984
Udassin R, Ariel I, Haskel Y, Kitrossky N, Chevion M: Salicylate as anin-vivo free radical trap: Studies on ischemic insult to the rat intestine. Free Radic Biol Med 10:1–6, 1991
Groner JI, Altschuler SM, Ziegler MM: The newborn piglet: A model of neonatal gastrointestinal motility. J Pediatr Surg 25:315–318, 1990
Ruckebusch M, Fioramonti J: Electrical spiking activity and propulsion in small intestine in fed and fasted rats. Gastroenterology 68:1500–1508, 1975
Gelman S, Feigenberg Z, Dintzman M, Levy E: Electroenterography after cholecystectomy. Arch Surg 112:580–583, 1977
Madsen JL, Larsen NE, Hilsted J, Worning H: Scintigraphic determination of gastrointestinal transit times. A comparison with breath hydrogen and radiologic methods. Scand J Gastroenterol 26:1263–1271, 1991
Derblom H, Johansson H, Nylander G: A simple method of recording quantitatively certain gastrointestinal motility functions in the rat. Acta Chir Scand 132:154–165, 1966
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Udassin, R., Eimerl, D., Schiffman, J. et al. Postischemic intestinal motility in rat is inversely correlated to length of ischemia. Digest Dis Sci 40, 1035–1038 (1995). https://doi.org/10.1007/BF02064193
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DOI: https://doi.org/10.1007/BF02064193