Summary
The effect of the immunostimulant C. parvum on the establishment and course of mycoplasma arthritis of mice was investigated. Male Swiss albino mice were injected intra-venously with M. arthritidis culture and intraperitoneally with C. parvum. It was shown that mice immunostimulated with C. parvum were significantly protected against the establishment of arthritis if the mycoplasma was given 9 days after the immunostimulant. However, when the arthritis was established C. parvum had no effect on the course of the arthritis. A close association between mycoplasma arthritidis and synovial cells in proposed as a possible explanation of this observation.
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Cole, B.C., Ward, J.R., Jones, R.S., Cahill, J.F. Chronic proliferative arthritis of mice induced by mycoplasma arthritidis. I. Induction of disease and histological characteristics. Infect. Immun., 1971, 4, 344–355.
Kaklamanis, E., Karalis, D., Drouga, M., Kaklamanis, Ph., Trichopoulos, D. Experimental mycoplasma arthritis as a model of human arthritis. II. Histopathological findings. Third Mediterranean and Middle Eastern Orthopaedic Surgery and Traumatology Congress. Athens 1974, Acta, 1974, 18–20.
Kaklamanis, E., Karalis, D., Drouga, M., Kaklamanis, Ph., Trichopoulos, D. Experimental arthritis induced by mycoplasma arthritidis. I. Clinical study. Iatriki, 1975, 27, 467–471.
Cole, B.C., Ward, J.R. Interaction of mycoplasma arthritidis and other myoplasmas with murine peritoneal macrophages. Infect. Immun., 1973, 7, 691–699.
Kaklamanis, E., Pavlatos, M. The immunosuppressive effect of mycoplasma infection. I. Effect on the humoral and cellula response. Immunology 1972, 22, 695–702.
Bergquist, L.M., Lau, B.H.S., Winter, C.E. Mycoplasma-associated immunosuppression. Effect on hemagglutinin response to common antigens in rabbits. Infect Immun., 1974, 9, 410–415.
Eckner, R.J., Han, T., Kumar, V. Enhancement of murine leukemia by mycoplasmas; suppression of cell-mediated immunity but not humoral immunity. Fed. Prod., 1974, 33, 769 (abstr.).
Gabridge, M.G., Schneider, P.R. Cytotoxic effect of mycoplasma fermentans on mouse thymocytes. Infect. Immun., 1975, 11, 460–465.
Halpern, B., Prévot, A.R., Biozzi, G., Stiffel, C., Mouton, D., Morard, J.C., Bouthillier, Y., Decreusefond, C. Stimulation de l'activité phagocytaire du système reticulo-endothelial provoqué par Corynebacterium parvum. J. Réticuloendothel Soc. 1964, 1, 77–96.
Simberkoff, M.S., Elsbach, P. The interaction in vitro between polymorphonuclear leukocytes and mycoplasma. J. Exp. Med., 1971, 134, 1417–1430.
Jones, T.C., Hirsch, J.G. The interaction in vitro of mycoplasma pulmonis with mouse peritoneal macrophages and L-cells. J. Exp. Med., 1971, 133, 231–259.
Powell, D.A., Clyde, W.A. Jr. Opsonin-reversible resistance of mycoplasma pneumoniae to in vitro phagocytosis by alveolar macrophages. Infect. Immun., 1975, 11, 540–550.
Volkman, A. Monocyte kinetics and their changes in infection. In: Immunobiology of the macrophages. Editor: Nelson, D.S. Academic press, Inc., 1976, 291–322.
Volkman, A. The origin and turnover of mononuclear cells in peritoneal exudates in rats. J. Exp. Med., 1966, 124, 241–254.
Furth van, R. The origin of phagocytic cells in the joint and bone. Scand. J. Rheumatol. 1981, suppl. 40, 13–20.
Barratt, M.E.J., Fell, H.B., Coombs, R.R.A., Glauert, A.M. The pgi synovium. II. Some properties of isolated intimai cells. J. Anat., 1977, 123, 47–66.
Edwards, J.C.W., Willoughby, D.A. Demonstration of bone marrow derived cells in synovial lining by means of giant intracellular granules as genetic markers. Ann. Rheum. Dis., 1982, 41, 177–182.
Zucker-Franklin, D., Davidson, M., Thomas, L. The interaction of mycoplasmas with mammalian cells. II. Monocytes and lymphocytes. J. Exp. Med., 1966, 124, 533–542.
Manchee, R.J., Taylor-Robinson, D. Studies on the nature of receptors involved in attachment of tissue culture cells to mycoplasmas. Br. J. Exp. Pathol., 1969, 50, 66–75.
Hollindale, M.R., Manchee, R.J. The role of mycoplasma membrane proteins in the absorption of animal cells to mycoplasma hominis colonies. J. Gen. Microbiol., 1972, 70, 391–393.
Clyde, W.A., Jr. Pathogenic mechanisms in mycoplasma diseases In: Microbiology. Editor: Schlessinger, D., American Society for Microbiology, Washington, D.C., 1975, 143–146.
Krause, D.K., Baseman, J.B. Mycoplasma pneumoniae proteins that selectively bind to host cells. Infect. Immun., 1982, 37, 382–386.
Fernald, G.W., Clyde, W.A., Denny, F.W. In Immunology of human infection. Part I. Bacteriae, mycoplasmas chlanidiae and fungi. Editors: Nahmias, A.G., O'Reilly, R.G. Plenum Medical Book Company, London 1981.
Cahill, J.F., Cole, B.C., Wilney, B.B., Ward, J.R. Role of biological mimicry in the pathogenesis of rat arthritis induced by mycoplasma arthritis. Infect. Immun., 1971, 3, 24–35.
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Kaklamani, E., Kaklamanis, P., Sparos, L. et al. Effect of corynebacterium parvum in the induction and course of mycoplasma arthritis of mice. Clin Rheumatol 2, 163–168 (1983). https://doi.org/10.1007/BF02032174
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DOI: https://doi.org/10.1007/BF02032174