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Correlation between tests of muscle involvement and clinical muscle weakness in polymyositis and dermatomyositis

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Summary

A correlation study was performed on the degree of muscle weakness in 36 patients with dermatomyositis and 69 with polymyositis in relation to muscle biopsy findings, electromyography (EMG) abnormalities, and serum concentrations of creatine kinase (CK), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzymes. Statistically significant correlations were found between muscle weakness and EMG results in patients with polymyositis, and between muscle weakness and serum CK and AST levels in dermatomyositis. As expected, correlations were found between the results of the three enzyme determinations in both groups of patients.

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References

  1. Vignos, P.J.Jr., Goldwyn, J. Evaluation of laboratory tests in diagnosis and management of polymyositis. Am J Med Sci 1972, 263, 291–308.

    PubMed  Google Scholar 

  2. Bohan, A., Peter, J.B. Polymyositis and dermatomyositis. N Engl J Med 1975, 292, 344–347, 403–407.

    PubMed  Google Scholar 

  3. De Vere, R., Bradley, W.G. Polymyositis: Its presentation, morbidity and mortality. Brain 1975, 98, 637–666.

    PubMed  Google Scholar 

  4. Bohan, A., Peter, J.B., Bowman, R.L., Pearson, C.M. A computer-assisted analysis of 153 patients with polymyositis and dermatomyositis. Medicine (Baltimore), 1977, 56, 255–286.

    Google Scholar 

  5. Henriksson, K.G. Polymyositis: Diagnosis, treatment and prognosis. Linköping University Medical Dissertations No. 100, 1980, Sweden.

  6. Edwards, R.H.T., Isenberg, D.A., Wiles, C.M., Young, A., Snaith, M.L. The investigation of inflammatory myopathy. J Roy Coll Physicians London, 1981, 15, 19–24.

    Google Scholar 

  7. Swash, M., Schwartz, M.S. Neuromuscular Diseases. A Practical Approach to Diagnosis and Management. 1981, Springer-Verlag, Berlin, pp. 235–240.

    Google Scholar 

  8. Hudgson, P., Peter, J.B. Classification. Clin Rheum Dis 1984, 10, 3–8.

    PubMed  Google Scholar 

  9. Payan, J. Electromyography in polymyositis and some related disorders. Clin Rheum Dis 1984, 10, 75–83.

    PubMed  Google Scholar 

  10. Benbassat, J., Gefel, D., Larholt, K., Sukenik, S., Morgenstern, V., Ziotnick, A. Prognostic factors in polymyositis/dermatomyositis. A computer-assisted analysis of ninety-two cases. Arthritis Rheum 1985, 28, 249–255.

    PubMed  Google Scholar 

  11. Hochberg, M.C., Feldman, D., Stevens, M.B. Adult onset polymyositis/dermatomyositis: An analysis of clinical and laboratory features and survival in 76 patients with a review of the literature. Semin Arthritis Rheum 1986, 15, 168–178.

    PubMed  Google Scholar 

  12. Kroll, M., Otis, J., Kagen, L. Serum enzyme, myoglobulin and muscle strength relationships in polymyositis and dermatomyositis. J Rheumatol 1986, 13, 349–355.

    PubMed  Google Scholar 

  13. Peiffer, J. Classification of myositis. Correlations between morphological and clinical classifications of inflammatory muscle disease. Pathol Res Pract 1987, 182, 141–156.

    PubMed  Google Scholar 

  14. Tymms, K., Webb, J. Dermatopolymyositis and other connective tissue diseases. A review of 105 cases. J Rheumatol 1985, 12, 1140–1148.

    PubMed  Google Scholar 

  15. Medical Research Council. Aids to the investigation of peripheral nerve injuries. Medical Research Council War Memo. 1943, 7.

  16. Currie, S. Inflammatory myopathies. Part I: Polymyositis and related disorders. In: Disorders of Voluntary Muscle. 4.th ed. Editor: J. Walton, Churchill Livingstone. Edinburgh 1981, pp. 537–547.

    Google Scholar 

  17. Fudman, E.J., Schnitzer, T.J. Dermatomyositis without creatine kinase elevation. A poor prognostic sign. Am J Med 1986, 80, 329–332.

    PubMed  Google Scholar 

  18. Nicholls, D. Dermatomyositis without creatine kinase elevation. Letter to the Editor. Am J Med 1987, 83, 182–183.

    Google Scholar 

  19. Medsger, T.A.Jr., Robinson, H., Masi, A.T. Factors affecting survivorship in polymyositis. A life-table study of 124 patients. Arthritis Rheum 1971, 14, 249–255.

    PubMed  Google Scholar 

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Tymms, K.E., Beller, E.M., Webb, J. et al. Correlation between tests of muscle involvement and clinical muscle weakness in polymyositis and dermatomyositis. Clin Rheumatol 9, 523–529 (1990). https://doi.org/10.1007/BF02030515

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