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Effects of the H2-antagonists famotidine and nizatidine and the cytoprotectant misoprostol on human colonic and rat peritoneal mast cells

  • Histamine Release and Mast Cells
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Abstract

The H2-antagonists famotidine and nizatidine produced a dose-dependent inhibition of histamine release from human colonic mucosal and muscle mast cells stimulated with anti-IgE. The IC30 values were in the range 0.5–10 μM and the maximum inhibition approached 50%. The compounds showed similar efficacy against rat peritoneal mast cells but were more potent. The cytoprotectant misoprostol had a striking effect on the human colonic mast cells, producing more than 50% inhibition at concentrations of 0.1–1 nM, but was much less active against the rat cells.

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Authors and Affiliations

  1. Department of Chemistry, University College London, Gower Street, WC1E 6BT, London, UK

    P. M. Shah & F. L. Pearce

  2. Department of Surgery, University College London, Gower Street, WC1E 6BT, London, UK

    P. B. Boulos & R. Vashisht

  3. Charing Cross Hospital, Fulham Palace Road, W6 8RS, London, UK

    R. Springall

Authors
  1. P. M. Shah
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  2. P. B. Boulos
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  3. R. Springall
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  4. R. Vashisht
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  5. F. L. Pearce
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Shah, P.M., Boulos, P.B., Springall, R. et al. Effects of the H2-antagonists famotidine and nizatidine and the cytoprotectant misoprostol on human colonic and rat peritoneal mast cells. Agents and Actions 41 (Suppl 1), C51–C52 (1994). https://doi.org/10.1007/BF02007763

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  • DOI: https://doi.org/10.1007/BF02007763

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