Abstract
Stroke is one of the most frequent complications of sickle cell disease (HbSS), occurring in 7–17% of children. Recent studies recognized more minor lesions on MRI, not associated with clinical signs on standard neurological examination, which however have been found to be a risk factor for developing stroke later. The aim of this study was to evaluate whether minor lesions observed on imaging could be associated with ‘soft’ neurological signs not detectable on conventional neurological examination. Fourteen children with HbSS were assessed with MRI, standard neurological examination and evaluation of ‘soft’ signs (Zurich Neuromotor Test) and motor function (Movement ABC). Eight of the 14 children scanned showed lesions on MRI but only 3 of the full cohort were abnormal on standard neurological examination. However, all of the eight children with MRI lesions also showed abnormal signs on at least one of the two tests (Zurich and Movement ABC). All the children with normal MRI were normal on all the tests performed. The sensitivity of Zurich Neuromotor Test and Movement ABC in the group of children with MRI lesions is 0.88 and 0.75, respectively, and increases to 1 when the two tests are used together. The specificity of both tests is 1 even when the tests are used separately.
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Abbreviations
- ACA :
-
anterior cerebral artery
- DWM :
-
deep white matter
- HbSS :
-
sickle cell disease
- ICA :
-
internal carotid artery
- MCA :
-
middle cerebral artery
- Movement ABC :
-
Movement Assessment Battery Children
- PCA :
-
posterior cerebral artery
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Mercuri, E., Faundez, J.C., Roberts, I. et al. Neurological ‘soft’ signs may identify children with sickle cell disease who are at risk for stroke. Eur J Pediatr 154, 150–156 (1995). https://doi.org/10.1007/BF01991921
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DOI: https://doi.org/10.1007/BF01991921