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Analysis of histamine actions by intra- and extracellular recording in hippocampal slices of the rat

  • Histamine and the Central Nervous System
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Abstract

Extra- and intracellular recordings from CAl pyramidal and dentate granule cells in hippocampal slices of the rat revealed a depressant effect of histamine which was usually accompanied by a hyperpolarization but no changes in conductance of the cell membrane. Synaptic potentials were unaffected. It is concluded that histamine has a post-synaptic action on ionic conductance in the dendrites, that allows a modulation of quick information transfer but no rapid synaptic transmission.

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Authors and Affiliations

  1. Neurochirurgische Universitätsklinik, CH-8091, Zürich, Switzerland

    Helmut L. Haas

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  1. Helmut L. Haas
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Supported by Swiss National Science Foundation grant No. 3396/78.

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Haas, H.L. Analysis of histamine actions by intra- and extracellular recording in hippocampal slices of the rat. Agents and Actions 11, 125–128 (1981). https://doi.org/10.1007/BF01991480

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