Abstract
The novel, peripherally acting opioid peptide, BW443C81, which attenuates airway sensory nerve impulses, was examined on non-cholinergic (NC) constrictor responsesin vitro andin vivo and neurogenic plasma extravasationin vivo in guinea-pig airways. Non-cholinergic contractions of guinea pig isolated bronchi, evoked by electrical field stimulation, were concentration-dependently inhibited by BW443C81 and morphine (10 nmol/l-100 μmol/l). In anaesthetised, artificially ventilated guinea pigs, frequency-related NC bronchoconstictor responses evoked by antidromic electrical stimulation of the vagus nerves were reduced by BW443C81 (100 μg/kg/min i.v. infusion) and morphine (1 mg/kg i.v.). Neurogenic plasma extravasation produced by bilateral electrical vagal nerve stimulation in spontaneously breathing, anaesthetised guinea pigs was also inhibited by BW443C81 (1 mg/kg i.v.). The inhibitory effects of BW443C81 were reversed/prevented by naloxone. BW443C81 inhibits NC bronchoconstrictor responses and neurogenic plasma extravasation in guinea pig airways, consistent with its previously described μ-opioid receptor-mediated inhibitory action on airway sensory nerve function.
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Shankley, C.E., Anderson, C.W.P. & Adcock, J.J. Effect of BW443C81, a novel opioid, on non-cholinergic bronchoconstrictor responses and neurogenic plasma extravasation in the guinea pig. Agents and Actions 36, 22–28 (1992). https://doi.org/10.1007/BF01991223
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DOI: https://doi.org/10.1007/BF01991223