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Species-dependent stereospecific serum protein binding of the oral anticoagulant drug phenprocoumon

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Summary

13 mammalian species are classified into 3 clearcut groups with respect to the stereospecific serum proteinbinding of phenprocoumon: 2 groups showing opposed stereospecific binding characteristics and a 3rd group exhibiting no stereospecific binding. Structural differences in the albumin molecule account for these stereospecific differences in serum protein-binding.

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Authors and Affiliations

  1. Department of Pharmacology, University of Mainz, Obere Zahlbacher Strasse 67, D-6500, Mainz, Federal Republic of Germany

    W. Schmidt & E. Jähnchen

Authors
  1. W. Schmidt
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  2. E. Jähnchen
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Additional information

This research was supported by a grant from the Deutsche Forschungsgemeinschaft (Ja/185/6).

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Schmidt, W., Jähnchen, E. Species-dependent stereospecific serum protein binding of the oral anticoagulant drug phenprocoumon. Experientia 34, 1323–1325 (1978). https://doi.org/10.1007/BF01981447

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