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Mechanism of the ketoconazole-cyclosporin interaction

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References

  • Anderson JE, Morris RE, Blaschke TF (1987) Ketoconazole potentiates cyclosporin immunosuppression and toxicity in mice. Transplant Proc 19: 1267–1268

    Google Scholar 

  • Bertauld-Peres P, Bonfils C, Fabre G, Sylvaine J, Cano J-P, Maurel PC (1987) Metabolism of cyclosporin A II Implication of the macrolide antibiotic inducible cytochrome P-450 3c from rabbit liver microsomes. Drug Metab Dispos 15: 391–398

    Google Scholar 

  • Charles BG, Ravenscroft PJ, Rigby RJ (1989) The ketoconazole-cyclosporin interaction in an elderly renal transplant patient. Aust NZ J Med 19: 292–293

    Google Scholar 

  • Daneshmend TK, Warnock DW (1988) Clinical pharmacokinetics of ketoconazole. Clin Pharmacokinet 14: 13–34

    Google Scholar 

  • Dieperink H, Moller J (1982) Ketoconazole and cyclosporin. Lancet ii: 1217

    Google Scholar 

  • D'Souza MJ, Pollock SH, Solomon HM (1988) Cyclosporin-cimetidine interaction. Drug Metab Dispos 16: 57–59

    Google Scholar 

  • Ferguson RM, Sutherland DER, Simmons RL, Najarian JS (1982) Ketoconazole, cyclosporin metabolism and renal transplantation. Lancet ii: 882–883

    Google Scholar 

  • First MR, Schroeder TJ, Weiskittel P, Myre SA, Alexander JW, Pesce AJ (1989) Concomitant administration of cyclosporin and ketoconazole in renal transplant recipients. Lancet ii: 1198–1190

    Google Scholar 

  • Henry MJ, Sisler HD (1984) Effects of sterol biosynthesis inhibiting (SBI) fungicides on cytochrome P-450 oxygenations in fungi. Pest Biochem Physiol 22: 262–275

    Google Scholar 

  • Huang Y-C, Colaizzi JC, Bierman RH, Woestenborghs R, Heykants J (1986) Pharmacokinetics and dose proportionality of ketoconazole in normal volunteers. Antimicrob Agents Chemother 30: 206–210

    Google Scholar 

  • Maurer G (1985) Metabolism of cyclosporin. Transplant Proc 17 [Suppl.1]: 19–26

    Google Scholar 

  • Maurer G, Loogli HR, Schreier E, Keller B (1984) Disposition of cyclosporin in several animal species and man. Drug Metab Dispos 12: 120–126

    Google Scholar 

  • Morgenstern GR, Powels R, Robinson B, McElwain TJ (1982) Cyclosporin interaction with ketoconazole and mephalan. Lancet ii: 1342

    Google Scholar 

  • Rodrigues AD, Gibson GG, Ioannides C, Parke DV (1987a) Interactions of imidazole antifungal agents with purified cytochrome P-450 proteins. Biochem Pharmacol 36: 4277–4281

    Google Scholar 

  • Rodrigues AD, Lewis DFV, Ioannides C, Parke DV (1987b) Spectral and kinetic studies of the interaction of imidazole anti-fungal agents with microsomal cytochrome P-450. Xenobiotica 17: 1315–1327

    Google Scholar 

  • Rowland M, Gupta SK (1987) Cyclosporin-phenytoin interaction: reevaluation using metabolic data. Br J Clin Pharmacol 24: 329–334

    Google Scholar 

  • Somogyi A, Gugler R (1982) Drug interactions with cimetidine. Clin Pharmacokinet 7: 23–41

    Google Scholar 

  • Venkataramanan R, Wang CP, Habucky K, Ptachcinsky RJ, Burckart GJ, Koneru B, Baker R, Todo S, Starzl TF (1988) Species specific cyclosporin metabolism. Transplant Proc 20: 680–683

    Google Scholar 

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Authors and Affiliations

  1. Biochemistry Dept., University of Surrey, GU2 5XH, Guildford, Surrey

    Eric Ah-Sing, Costas Ioannides & Laurence J. King

  2. Sandoz Pharmaceuticals, Frimley, GU16 5SG, Camberley, Surrey, UK

    Thomas W. Poole

Authors
  1. Eric Ah-Sing
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  2. Thomas W. Poole
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  3. Costas Ioannides
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  4. Laurence J. King
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Ah-Sing, E., Poole, T.W., Ioannides, C. et al. Mechanism of the ketoconazole-cyclosporin interaction. Arch Toxicol 64, 511–513 (1990). https://doi.org/10.1007/BF01977638

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  • DOI: https://doi.org/10.1007/BF01977638

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